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More common associations found between BRCA1 and BRCA2 mutations and cancer

BRCA1 and BRCA2 mutations may be more common in the general population than previously reported and may be associated with ovarian, breast, testicular and pancreatic cancers, according to a study in the Dec. 6 issue of the Journal of the National Cancer Institute.

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Keywords: associations, brca1, brca2, mutations, cancer, association, mutation

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1. Breast cancer risk varies among women who are carriers of BRCA1 and BRCA2 gene mutations
   01-08-2008 · EurekAlert!
   Breast cancer risk varies widely among women who are carriers of the BRCA1 and BRCA2 mutations, according to a new study published in the Jan. 9, 2008, issue of the Journal of the American Medical Association.
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2. Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
   01-01-2008 · EurekAlert!
   Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.
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3. Benefit of cancer prevention surgery differs between women with BRCA1 and BRCA2 mutations
   02-11-2008 · EurekAlert!
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4. Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers
   01-08-2008 · EurekAlert!
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5. Personalized medicine can cut breast cancer risk
   02-15-2008 · EurekAlert!
   The time has come for breast cancer risk assessment, counseling and genetic testing to move from cancer specialists to the realm of primary care. A growing body of evidence has documented the benefits of preventive measures for high-risk women including those with mutations in the BRCA1 and BRCA2 genes. Referral for cancer-risk assessment and BRCA testing in the primary care setting is a necessary step towards personalized medicine for women at risk.
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6. New study reveals for first time how BRCA1 mutations cause breast cancer
   12-09-2007 · EurekAlert!
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7. Varying prevalence among ethnic groups of gene mutation that increases risk of breast cancer
   12-25-2007 · EurekAlert!
   Among several US racial/ethnic groups examined, Hispanic women were found to have the highest prevalence of the cancer-associated gene mutation BRCA1 at 3.5 percent, with Asian Americans having the lowest prevalence (0.5 percent), according to a study in the Dec. 26 issue of JAMA.
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8. Cancer that colonizes our bodies
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   Tomorrow AAAS Fellow, Robert C. von Borstel will talk about how cancer cell mutation and selection are metaphorically similar to the evolution of a new species.Like the first pregnant finch that landed in the Galapagos, the first cancer cell in a body has to undergo many mutations through many generations to establish itself. But once there, like any newly stabilized species in different ecological niches, cancer is tough to get rid of.
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10. Other Highlights in the Nov. 27 JNCI
    11-27-2007 · EurekAlert!
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