science top stories popular news  

Daily non-political popular news in brief.

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

12-07-2006 · EurekAlert!

Researchers at the Salk Institute for Biological Studies in collaboration with scientists at the University of California, San Diego took a high resolution "action shot" of a protein switch that plays a crucial role in the development of the nervous system. Their findings, published in the December 8 issue of the journal Molecular Cell, provide a template for the design of small molecule inhibitors to control that switch, a protein called Scp1, at will.

Read more »

Keywords: detailed, 3-d, image, catches, key, regulator, neural, stem, cell, differentiation, action, catche

« Previous | Next »

Similar news on "Detailed 3-D image catches a key regulator of neural stem cell differentiation in action":

  1. Neural stem cell study reveals mechanism that may play role in cancer
    09-04-2007 · EurekAlert!
    In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
    Similar news · Read more »
  2. Neuronal differentiation of human neural stem cell grafts in adult rat spinal cord
    02-12-2007 · EurekAlert!
    New results challenge previous assumptions that the spinal cord is unable to support the differentiation of neurons from stem cell grafts.
    Similar news · Read more »
  3. Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
    06-19-2007 · EurekAlert!
    A team of Canadian scientists has identified 1,155 genes under the control of a gene called Oct4 considered to be the master regulator of the stem cell state. The study will be published in the June 20 edition of the online, open-access journal PLoS ONE.
    Similar news · Read more »
  4. Identification of a novel neural stem cell type
    01-14-2008 · EurekAlert!
    As published in the upcoming issue of G&D, sesearchers from the Sloan-Kettering Institute, led by Dr. Lorenz Studer, have discovered a novel type of neural stem cell, which has a broader differentiation potential than previously identified neural stem cells.
    Similar news · Read more »
  5. Researchers discover important tool in understanding differentiation in human embryonic stem cells
    10-24-2007 · EurekAlert!
    Researchers at the University of Minnesota's Stem Cell Institute have used an existing genetic tool to study how human embryonic stem cells self-renew. The researchers used "knockdown" technology to reduce the expression, and plasmid vectors to increase the expression of oct4, a gene known to be necessary for self renewal. Both procedures resulted in differentiation, but with similar patterns, unlike mouse ES cells that differentiate into a different cell types with oct4 up-and down-regulation.
    Similar news · Read more »
  6. Trainor Lab characterizes gene essential for prenatal development of nervous system
    02-01-2008 · EurekAlert!
    The Stowers Institute's Trainor Lab has demonstrated the role of a gene important to the embryonic development of the nervous system, a process that requires coordination of differentiation of immature neural cells with the cycle of cell division that increases their numbers. Until now, the mechanisms regulating these distinct cellular activities have been poorly understood.
    Similar news · Read more »
  7. How many genes does it take to learn? Lessons from sea slugs
    12-28-2006 · EurekAlert!
    At any given time within just a single brain cell of sea slug known as Aplysia, more than 10,000 genes are active, according to scientists writing in Cell. Researchers also analyzed 146 human genes implicated in 168 neurological disorders, including Parkinson's and Alzheimer's diseases, and genes controlling aging and stem-cell differentiation. They found 104 counterpart genes in Aplysia, suggesting it will be a valuable tool for developing treatments for neurodegenerative diseases.
    Similar news · Read more »
  8. Milestone in the regeneration of brain cells
    08-20-2007 · EurekAlert!
    Neuherberg, 20 Aug. The research group of Prof. Dr. Magdalena Gцtz at the Institute of Stem Cell Research of the GSF -- National Research Centre for Environment and Health, and the Ludwig Maximilians University, Munich, has achieved an additional step for the potential replacement of damaged brain cells after injury or disease: functional nerve cells can be generated from astroglia, a type of supportive cells in the brain by means of special regulator proteins.
    Similar news · Read more »
  9. Adult stem cells lack key pluripotency regulator
    10-10-2007 · EurekAlert!
    The protein Oct4, which helps to maintain embryonic stem cells, has been shown to be virtually absent in adult stem cells. These results question the findings of more than 50 studies that found Oct4 in various adult stem cells, and put claims of pluripotent adult stem cells into perspective.
    Similar news · Read more »
  10. Signaling for cartilage
    11-27-2006 · EurekAlert!
    Skeletal progenitor cells differentiate into cartilage cells when one master gene actually suppresses the action of another. Skeletons are made of bone and cartilage cells that are differentiated from the same multipotent stem cell, which gives rise to bone, cartilage, fat and fibroblasts.
    Similar news · Read more »