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Aggressive stem cells might improve transplant outcome

Investigators at St. Jude Children's Research Hospital have demonstrated in mice a way that might reduce the time it takes for a bone marrow transplant to rebuild a child's immune system, and so reduce the risk of potentially fatal virus infections that can occur during this time.

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Keywords: aggressive, stem, cells, improve, transplant, outcome, cell

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1. Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
   11-22-2007 · EurekAlert!
   Researchers at the Stanford University School of Medicine have taken a small but significant step, in mouse studies, toward the goal of transplanting adult stem cells to create a new immune system for people with autoimmune or genetic blood diseases.
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2. U of MN adult stem cell research shows promise for transplant therapies
   01-15-2007 · EurekAlert!
   University of Minnesota stem cell researchers, together with collaborators at Stanford University, have successfully used adult stem cells to replace the immune system and bone marrow of mice, offering the promise of new therapies for people in the future.
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3. A faster way to recover from chemotherapy and marrow transplant
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4. Long-term cancer risk follows stem cell transplant recipients
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5. African-Americans receive fewer stem cell transplants than whites
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   02-01-2007 · EurekAlert!
   Treatment for skin cancer by infusion of tumor-reactive T cells requires patients to be pre-treated with agents that transiently decrease the number of immune cells (nonmyeloablative agents). A study in mice now indicates that pre-treatment with more intense immune cell-depleting strategies (known as myeloablative strategies) and a hematopoietic stem cell transplant enables infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmyeloablative agents, and this correlates with increased tumor regression.
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