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New biomarker predicts effectiveness of breast cancer drugs
12-07-2006 · EurekAlert!University of Cincinnati researchers have identified a new way to predict when anti-estrogen drug therapies are inappropriate for patients with hormone-dependent breast cancer.Scientists say these findings could help physicians more accurately predict which tumors will respond to anti-estrogen therapy and improve long-term survival for breast cancer patients.
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Keywords: biomarker, predicts, effectiveness, breast, cancer, drugs, predict, drug
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- MIT model could predict cells' response to drugs
07-30-2007 · EurekAlert!
MIT researchers have developed a model that could predict how cells will respond to targeted drug therapies. Models based on this approach could help doctors make better treatment choices and drug developers identify the ideal compound. In addition, the model could help test the effectiveness of drugs for a wide range of diseases, including cancer, arthirtis, and immune system disorders.
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- Blocking cancer-causing gene improves radiation effectiveness, Jefferson researchers find
11-08-2006 · EurekAlert!
Inhibiting a particular cancer-causing gene can enhance the cell-killing effects of radiation, a team of radiation oncologists and cancer biologists has found. Using a combination of zebrafish and antisense technology, they've shown that the drug flavopiridol works by blocking the activity of a gene, cyclin D1, which is overexpressed in about half of all breast cancers. Similar techniques in the future, the scientists say, may enable researchers to better gauge the effects of drugs.
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- Mice predict the effectiveness of orally taken drugs
11-01-2007 · EurekAlert!
More than half of all orally-prescribed medications are broken down in the intestine and liver by an enzyme known as CYP3A before reaching their site of action. Researchers from the Netherlands Cancer Institute have now developed a mouse model for predicting the loss in available drug due to first-pass metabolism by CYP3A, providing a tool to help predict whether drugs being developed will work effectively if given orally.
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- A new computational technique predicts side-effects of a major cancer drug
11-27-2007 · EurekAlert!
Researchers at the University of California San Diego have developed a novel computer technique to search for the side effects of major pharmaceuticals. The study, reported Nov. 30 in PLoS Computational Biology, relates to a class of drugs known as Select Estrogen Receptor Modulators, which includes tamoxifen, the most prescribed drug in the treatment of breast cancer.
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- Mouse tests predict drug response in relapsing pancreatic cancer patients
10-11-2006 · EurekAlert!
By slicing up bits of patient tumors and grafting them into mice, Johns Hopkins Kimmel Cancer Center specialists have figured out how to accurately "test drive" chemotherapy drugs to learn in advance which drug treatments offer each individual pancreatic cancer patient the best therapeutic journey.
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- Quest for better breast cancer drugs
11-27-2006 · EurekAlert!
Breast cancer sufferers could eventually benefit from high-tuned, tailor-made drug treatments that minimize side effects as a result of a joint initiative between computer scientists in Edinburgh and cellular biologists in Japan.
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- Breast cancer susceptibility gene predicts outcome and response to treatment in lung cancer
09-25-2007 · EurekAlert!
Researchers have found that the breast cancer susceptibility gene, BRCA1, plays a significant role in nonsmall cell lung cancer. They told the European Cancer Conference in Barcelona that not only can it be used to predict outcome for patients with NSCLC, but it may also prove to be a valuable tool in choosing the best therapy for them.
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- Protein-based tumor biomarker predicts breast-cancer survival
12-05-2006 · EurekAlert!
The first and largest clinical trial of its kind confirms that a protein called p27 may be a valuable tool for predicting survival after a diagnosis of breast cancer.
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- Other highlights in the Dec. 6 JNCI
12-05-2006 · EurekAlert!
Other highlights in the Dec. 6 JNCI include an Italian model that predicts the risk of breast cancer, a study showing chemotherapy can cause a cognitive decline in some patients, a common genetic variant that is linked to drug-induced diarrhea, a protein that signals poor prognosis in some breast cancer patients and specific genetic changes that are linked to colon cancer in smokers.
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- New test predicts blood cancer's sensitivity to experimental cancer drug
01-22-2007 · EurekAlert!
A test developed by Dana-Farber Cancer Institute scientists is the first to identify which malignant blood cells are highly vulnerable to a promising type of experimental drugs that unleash pent-up "cell suicide" factors to destroy the cancer.
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