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T-beta-RIII joins the fight against breast cancer

Although the soluble factor TGF-beta suppresses tumor cell growth in early breast cancer, high TGF-beta levels later in disease are associated with a poor outcome. A new study using human breast cancer samples and mice, indicates that changes in expression of one TGF-beta receptor component, T-beta-RIII, might explain the distinct effects of TGF-beta at the different stages of breast cancer and that analysis of T-beta-RIII levels might help clinicians decide how aggressively to treat patients.

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Keywords: t-beta-riii, joins, fight, breast, cancer, beta, riii, join

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