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Mutant mouse provides insights into breast cancer

By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between genetic defects in DNA replication and breast cancer.

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Keywords: mutant, mouse, provides, insights, breast, cancer, provide, insight

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1. Enhanced DNA-repair mechanism can cause breast cancer
   10-15-2007 · EurekAlert!
   Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists provide insight into how the normal BRCA1 gene suppresses the growth of tumors as well as the nature of the genetic instability that leads to cancer when BRCA1 is defective.
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2. Genetic approach provides new insight into trastuzumab resistance in breast cancer
   10-15-2007 · EurekAlert!
   A new study provides important insight into the mechanisms involved in resistance to treatment of breast cancer patients with trastuzumab (Herceptin). The research, published by Cell Press in the October issue of the journal Cancer Cell, identifies markers that may help to identify patients who are unlikely to respond to trastuzumab treatment and provides a potential strategy for treating these patients.
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3. New 'knock-out' gene model provides molecular clues to breast cancer
   09-05-2007 · EurekAlert!
   New insights into the role of estrogen receptor in mammary gland development may help scientists better understand the molecular origin of breast cancer, according to new research from the University of Cincinnati.
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4. Mouse FH knockout resembles human renal cell cancer
   04-09-2007 · EurekAlert!
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5. Tailored treatments: Promising designer drug provides new insight into cancer biology
   11-13-2006 · EurekAlert!
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6. New antibody for EGFR causes lung cancer regression
   01-25-2007 · EurekAlert!
   Mutant forms of the protein EGFR are involved in lung cancer development in many individuals, but not all individuals express the same mutant EGFR. A new study shows that both a mouse EGFR-specific antibody (mAb806) and its humanized form (ch806) cause lung tumor regression in two mouse models of lung cancer, leading to the suggestion that ch806 might provide a new approach to treat patients with lung cancer driven by mutant forms of EGFR.
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7. Queen's discovery provides new hope for people with advanced breast cancer
   01-15-2007 · EurekAlert!
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8. Residual fetal cells in women may provide protection against breast cancer
   10-01-2007 · EurekAlert!
   Fetal cells that persist in a woman's body long after pregnancy -- a common occurrence known in scientific circles as fetal microchimerism -- in some cases may reduce the woman's risk of breast cancer, according to researchers at Fred Hutchinson Cancer Research Center.
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9. Researchers identify unusual molecular switch for common form of advanced breast cancer
   11-08-2007 · EurekAlert!
   New evidence demonstrates that a novel molecular switch is involved in the development of a common form of advanced breast cancer, known as locally advanced breast cancer. The research, published by Cell Press in the Nov. 9, 2007 issue of Molecular Cell, provides an exciting paradigm shift in the understanding of a key event in breast cancer development and presents new therapeutic opportunities for this deadly disease.
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10. New vaccine may provide broader protection against cervical cancer
    06-28-2007 · EurekAlert!
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