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Genetic mechanism helps explain chronic pain disorders
12-22-2006 · EurekAlert!Researchers at the University of North Carolina at Chapel Hill have discovered that commonly occurring variations of a gene trigger a domino effect in chronic pain disorders. The finding might lead to more effective treatments for temporomandibular joint disorder (TMJD) and other chronic pain conditions.
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Keywords: genetic, mechanism, explain, chronic, pain, disorders, disorder
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- How genetic malfunction causes a form of retardation
04-18-2007 · EurekAlert!
Researchers have discovered that the genetic malfunction that causes a form of mental retardation called Noonan Syndrome produces an imbalance in the genesis of two types of cells in the developing embryonic brain. This imbalance, they theorize, could explain how the genetic abnormality gives rise to the neural pathology of the disorder. More broadly, they said, the new insight into the mechanism underlying NS could apply to other inherited forms of retardation.
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- Origin of inherited pain disorder pinpointed
12-06-2006 · EurekAlert!
The genetic basis for a rare inherited disorder that causes severe burning pain with no warning has been pinpointed by researchers. They found that paroxysmal extreme pain disorder (PEPD) is caused by specific mutations in porelike sodium channels in peripheral nerve cells -- a discovery that they said emphasizes the role of such channel disorders in inflammatory pain. Such findings of abnormal function in disease also provide insights into the normal function of such channels, they said.
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- Gene discovery aids understanding of common inherited neurological disorder
06-21-2007 · EurekAlert!
Thanks to a randomly appearing strain of "pale tremor" lab mice, the multi-university research team was rapidly able to track down the gene responsible for similar disability in people. The work, published online in the Journal Nature, paves the way for future genetic tests and later on, possible treatments for a small percentage of people with Charcot-Marie-Tooth disorder, which causes leg pain, muscle weakness and foot deformities.
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- Gabapentin shown effective for fibromyalgia pain
06-11-2007 · EurekAlert!
New research supported by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases shows that the anticonvulsant medication gabapentin, which is used for certain types of seizures, can be an effective treatment for the pain and other symptoms associated with the common, often hard-to-treat chronic pain disorder, fibromyalgia.
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- Genetic mutation explains form of brittle bone disease
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A newly identified gene mutation helps explain a subset of cases of osteogenesis imperfecta, or brittle bone disease, whose origin had until now remained mysterious. Identifying the new mutation is important because children with the disorder, whose bones break easily, are sometimes mistaken as victims of child abuse -- particularly those who do not carry the genetic mutation known to cause most cases of brittle bone disease.
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- Reversal of symptoms in an autism spectrum disorder
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The Rett Syndrome Research Foundation announces results of a landmark study reversing the symptoms of Rett Syndrome in a genetic mouse model. The findings, by Adrian Bird, Ph.D., of the University of Edinburgh and Chairman of the RSRF Scientific Advisory Board, appear online in Science Express on February 8, 2007. Rett Syndrome is a severe childhood neurological disease that is the most physically disabling of the autism spectrum disorders. The experiments were funded in part by the Rett Syndrome Research Foundation.
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- New study examines brain-gut relationship in those suffering with stomach pain or discomfort
09-05-2007 · EurekAlert!
A new clinical study will explore the brain-gut interaction in patients with functional dyspepsia and whether certain drugs can effectively relieve symptoms of this disorder. Functional dyspepsia is a costly and chronic disorder that can cause severe stomach pain often reported as cramping, bloating and gas, or great discomfort or fullness after eating. The study is funded by the National Institutes of Health at six medical centers in the US.
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- New mechanism underlying pain found
10-15-2006 · EurekAlert!
Researchers at Johnson & Johnson Pharmaceutical Research & Development (J&JPRD) today announced that they have discovered a new molecular mechanism that may underlie neuropathic pain. The clearer understanding of the root-cause of chronic neuropathic pain, and the preclinical validation of new targets for pharmaceutical therapies shown in this research, together present an opportunity for the development of new ways to treat the severe pain associated with such common conditions or diseases as sciatica, diabetic neuropathy and shingles.
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- Genes key to high liver cancer rates in men
01-15-2008 · Massachusetts Institute of Technology (MIT)
A fundamental difference in the way males and females respond to chronic liver disease at the genetic level helps explain why men are more prone to liver cancer, according to MIT researchers, who conducted the first genome-wide study on the subject.
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