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Profiling of cancer genes may lead to better and earlier detection of solid human cancers
12-27-2006 · UT Southwestern Medical CenterA research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers — lung, breast, prostate and colon cancer.
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Keywords: profiling, cancer, genes, lead, earlier, detection, solid, human, cancers, gene
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- Profiling of cancer genes may lead to better and earlier detection
12-25-2006 · EurekAlert!
A research team at UT Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers -- lung, breast, prostate and colon cancer.
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- AVN944 inhibits IMPDH & induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- Fat kills cancer
07-03-2007 · EurekAlert!
Researchers in Slovakia have been able to derive mesenchymal stem cells from human adipose, or fat, tissue and engineer them into "suicide genes" that seek out and destroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack small tumor metastases that evade current detection techniques and treatments, the researchers conclude in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.
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- AVN944 inhibits IMPDH and induces apoptosis-related biomarkers in patients with hematologic cancers
12-11-2006 · EurekAlert!
IMPDH is highly upregulated in most hematological cancers and solid tumors -- an essential role in cancer cell synthesis of DNA and RNA. Inhibition of IMPDH represents a new and important approach to treat cancer. In a Phase I trial of AVN944, AvalonRx identified a set of 34 genes. These gene markers correlate with the biochemical effects of AVN944 on protein function -- believed to result in tumor cell apoptosis at the right doses.
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- 2 heads are better than 1: 2 dysfunctional DNA repair pathways kill tumor cells
04-12-2007 · EurekAlert!
Individuals who inherit one mutant copy of any one of about 12 genes that make the proteins of the Fanconi Anemia pathway are at increased risk of developing cancer. This occurs when the remaining "good" copy of the gene becomes mutated in a specific cell type. However, hope of a new treatment for these cancers has now been provided by a new study indicating that inhibiting the protein ATM can kill these cancer cells.
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- Cancer cures could work for canines and humans
07-12-2007 · EurekAlert!
One of the major issues associated with longer life expectancy in man and his best friend is an increase in the incidence of cancer. Even though they cannot talk, it seems dogs might be able to tell us why and how certain cancers develop. In turn that could lead to better treatments for both canine and human cancer patients.
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- First familial pancreatic cancer gene identified
12-11-2006 · EurekAlert!
At least 10 percent of pancreatic cancers are thought to be familial, i.e., caused by inherited genetic mutations. The responsible genes have so far remained elusive, but one of the research teams that had been on a pancreatic cancer gene hunt for years now reports success: Teri Brentnall (University of Washington), David Whitcomb (University of Pittsburgh), and colleagues publish the identification of the palladin gene as the one mutated in a large family they had been studying for a while.
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- Ashkenazi ovarian cancer patients with BRCA mutations live longer than those with normal gene
01-01-2008 · EurekAlert!
Israeli investigators have found that Ashkenazi Jewish women with ovarian cancer who have mutations in the BRCA1 or BRCA2 genes lived significantly longer than Ashkenazi Jewish ovarian cancer patients without these mutations. After up to nine years of follow-up, BRCA1/2 mutation carriers were 28 percent less likely to die from the disease, even though women with the BRCA mutations are significantly more likely to develop ovarian and breast cancers.
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- Selective marker found to indicate aggressive form of breast cancer
01-15-2007 · EurekAlert!
Researchers have linked a structural protein called nestin to a particularly deadly form of breast cancer, identifying a new biomarker that could lead to earlier detection and better treatment.
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- Study shows no survival benefit for CT screening for lung cancer
03-06-2007 · EurekAlert!
The first report of an international study looking at computed tomography (CT) to screen current or former smokers for lung cancer found that screening did not reduce deaths from lung cancer. Although CT screening found nearly three times as many lung cancers as predicted, the researchers found that early detection and treatment did not lead to a corresponding decrease in advanced lung cancers or a reduction in deaths from lung cancer.
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