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Sex differences and rheumatoid arthritis

A humanized mouse model may be valuable for not only studying sex differences in RA, but also for understanding why women are particularly vulnerable to autoimmunity and for developing future therapeutic strategies.

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Keywords: sex, differences, rheumatoid, arthritis, difference, arthriti

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1. Rheumatoid Arthritis And Sex Differences
   09-29-2006 · ScienceDaily
   To thoroughly investigate sex differences in RA, a team of researchers turned to families with a history of the disease among both their female and male members. The results indicate that male sex exerts a significant influence on underlying RA mechanisms, particularly the production of anti-CCP antibodies.
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2. Mapping rheumatoid arthritis -- first multinational review of RA shows
   06-14-2007 · EurekAlert!
   In the first international "map of rheumatoid arthritis," spanning Europe and beyond, significant national differences in RA severity can be directly traced to national economics, most notably health expenditure, as exposed today by data from the QUEST-RA Study presented at EULAR 2007, the Annual Congress of the European League Against Rheumatism, Barcelona, Spain.
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3. How are phenotypic differences between sexes related to phenotypic variation within sexes?
   01-10-2007 · EurekAlert!
   It has long been recognized that sexually dimorphic traits -- traits that are systematically different between members of different sex in the same species, such as peacocks' tail feathers -- tend to vary a great deal among individual males, and that much of this within-sex variation depends on individual condition. Indeed, theory predicts that sexual dimorphism will evolve based on condition dependence so that, among traits, a more pronounced difference between male and female should be associated with a stronger response to variation in condition.
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4. Mayo study examines link between rheumatoid arthritis and chronic lung diseases
   11-16-2006 · EurekAlert!
   For decades, researchers have suspected a connection between chronic lung diseases and rheumatoid arthritis.
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5. Green tea compound suppresses factors causing cartilage, bone destruction in arthritis
   04-29-2007 · EurekAlert!
   In rheumatoid arthritis, a person's own immune system attacks the joints by activating the synovial tissue that lines the body’s movable joints, causing inflammation, swelling, pain and eventually erosion of the bone and cartilage and deformation of the joint. Dr. Salah-uddin Ahmed reports that a compound derived from green tea was able to inhibit production of several immune system molecules involved in inflammation and joint damage.
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6. Enbrel safety data for up to 8 years in patients with juvenile rheumatoid arthritis
   06-13-2007 · EurekAlert!
   Amgen and Wyeth Pharmaceuticals, a division of Wyeth, today announced the presentation of additional data that showed that the safety profile of Enbrel was maintained with long-term use in patients with moderate-to-severe juvenile rheumatoid arthritis who completed up to eight years of therapy. The study results will be presented at the European League Against Rheumatism Annual Congress, an international rheumatology meeting, in Barcelona, Spain.
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7. Do static magnets reduce pain?
   09-24-2007 · EurekAlert!
   Static magnets are widely marketed to the public with claims of effectiveness for relieving pain. One survey suggests that about 28 percent of patients with rheumatoid arthritis, osteoarthritis or fibromyalgia, use magnets or copper bracelets for pain relief. Do static magnets help reduce pain?
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8. Sex differences in the brain's serotonin system
   02-13-2008 · EurekAlert!
   A new thesis from the Swedish medical university Karolinska Institutet shows that the brain's serotonin system differs between men and women. The scientists who conducted the study think that they have found one of the reasons why depression and chronic anxiety are more common in women than in men.
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9. Cancer Drug May Be Remedy For Rheumatoid Arthritis, Study Finds
   09-30-2006 · ScienceDaily
   The potent cancer drug Gleevec, used to combat leukemia and some gastrointestinal cancers, may be useful in treating rheumatoid arthritis, according to a team of researchers at the Stanford University School of Medicine.
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10. Annals of Internal Medicine tip sheet for March 20, 2007
    03-19-2007 · EurekAlert!
    The following articles are featured in the upcoming Annals of Internal Medicine: "Flexible Use of Drugs with Close Patient Follow-up Can Successfully Control Rheumatoid Arthritis;" "Osteoporosis Drug Strengthens Bones in Men with Prostate Cancer," and "Experts Show Physicians How to Initiate and Carry Through Timely and Effective Discussions about Hospice with Dying Patients."
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