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Filling a niche -- role of Rb in mammalian stem cells
12-31-2006 · EurekAlert!In the January 1 issue of G&D, Drs. Gustavo Leone and Michael Robinson (Ohio State University) and colleagues uncover a stem-cell specific role for the well-known tumor suppressor gene, Rb, in the developing mammalian embryo.
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Keywords: filling, niche, role, mammalian, stem, cells, cell
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- Discovery of cardiac stem cells may advance regenerative heart therapy
11-22-2006 · EurekAlert!
An immediate early publication of the journal Cell, published by Cell Press, on Nov. 22, 2006, points to the possible existence of master cardiac stem cells with the capacity to produce all three major tissues of the mammalian heart. A companion Cell paper also published online reports the discovery of a second population of cardiac progenitors, which are capable of forming both cardiac muscle and the smooth muscle found in the heart's blood vessel walls.
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- Neural stem cell study reveals mechanism that may play role in cancer
09-04-2007 · EurekAlert!
In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
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- Xie Lab characterizes niche control of stem cell function
01-10-2008 · EurekAlert!
The Stowers Institute's Xie Lab has published findings that begin to characterize the poorly understood interaction among stem cells within their cellular microenvironment, called a niche.
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- Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
01-17-2008 · EurekAlert!
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.
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- Mass. General researchers identify master cardiac stem cell
11-22-2006 · EurekAlert!
Researchers from the Massachusetts General Hospital Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major cell types of the mammalian heart. In a report to appear in the journal Cell, receiving early online release, they describe identifying these progenitor cells in mice, cloning them from embryonic stem cells, and showing that cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.
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- Stem cells get a grip
12-14-2006 · EurekAlert!
At the American Society for Cell Biology's 2006 conference, scientists will describe how live cell imaging has revealed the very close relationship of hematopoietic stem cells and osteoblasts in the stem cell niche.
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- Scientists discover stage at which an embryonic cell is fated to become a stem cell
01-10-2007 · EurekAlert!
Cambridge scientists have discovered the stage at which some of the cells of a fertilized mammalian egg are fated to develop into stem cells and why this occurs. The findings of the study, which overturn the long-held belief that cells are the same until the fourth cleavage (division) of the embryo, are reported in today's edition of Nature.
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- JCI table of contents: Feb. 1, 2007
02-01-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published Feb. 1, 2007, in the JCI, including: New role in asthma for old drug; Tumor-reactive T cells boosted by hematopoietic stem cell transplantation; p21 stops HIV-1 in its tracks in hematopoietic stem cells; What makes epithelial cells change their identity?; NOTCHing up heart development; Stress response prevents neurodegeneration, and 4E-BP1 and 4E-BP2 stop mice getting fat.
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- Algae provide new clues to cancer
10-12-2006 · EurekAlert!
A microscopic green alga helped scientists at the Salk Institute for Biological Studies identify a novel function for the retinoblastoma protein (RB), which is known for its role as a tumor suppressor in mammalian cells. By coupling cell size with cell division, RB ensures that cells stay within an optimal size range.
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- Scientists unlock mystery of embryonic stem cell signaling pathway
03-19-2007 · EurekAlert!
A newly discovered small molecule called IQ-1 plays a key role in preventing embryonic stem cells from differentiating into one or more specific cell types, allowing them to instead continue growing and dividing indefinitely, according to research performed by a team of scientists who have recently joined the stem-cell research efforts at the Keck School of Medicine of the University of Southern California.
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