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Jefferson scientists find guardian gene's choices crucial to stopping cancer process
01-05-2007 · EurekAlert!Scientists at the Kimmel Cancer Center at Thomas JeffersonUniversity have uncovered a novel pathway by which the anti-cancer gene p53 springs into action, protecting a damaged cell from becoming cancer. The gene can either halt the cell's growth or send it spiraling toward certain death. How this choice is made, the researchers say, could have implications for future strategies in chemotherapy drug development.
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Keywords: jefferson, scientists, guardian, gene, choices, crucial, stopping, cancer, process, scientist, choice
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- Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
01-17-2008 · EurekAlert!
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- Jefferson scientists see breast cancer gene activity from outside the body
11-28-2007 · EurekAlert!
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body. This technology might someday help physicians to detect and classify cancer, enabling them to find cancerous breast tumors as early as possible, and determine the appropriate treatment.
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- Common cancer gene sends death order to tiny killer
05-31-2007 · EurekAlert!
Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for -- stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell.
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- Jefferson scientists show gene reverts cancer genes to normal, predicts breast cancer prognosis
10-31-2006 · EurekAlert!
Scientists have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer. They looked at cancer cells from more than 2,000 breast cancer patients and found that this commandeering or "organizing" ability is increasingly lost in cancer cells and associated with the progression of disease. The more the gene is expressed in breast cancer, the better the patient did.
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- Blood pressure drugs could help halt pancreatic cancer spread, Jefferson researchers find
12-07-2006 · EurekAlert!
Common blood pressure medications might help block the spread of pancreatic cancer, researchers have found. The scientists showed in laboratory studies that two types of pressure-lowering drugs -- ACE inhibitors and AT1R blockers -- may help reduce the development of tumor-feeding blood vessels, a process called angiogenesis. Such drugs, they say, may become part of a novel strategy to control the growth and spread of cancer.
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- Jefferson scientists identify protein key to breast cancer spread, potential new drug target
04-09-2007 · EurekAlert!
Researchers at the Kimmel Cancer Center at Jefferson have identified a protein that they say is key to helping a quarter of all breast cancers spread. The finding, reported online the week of April 9, 2007, in the journal Proceedings of the National Academy of Sciences, could be a potential target for new drugs aimed at stopping or slowing the growth and progression of breast cancer.
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- Pathway to cell death redefined in landmark study
09-20-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine have determined that an intracellular protein called serpin-6 is crucial to the repair and survival of cell injury. Controlling the process could pave the way to new treatments for cancer, stroke, heart disease, neurological disorders and other killer illnesses. Using a primitive animal model, the scientists also have made cascade of cell death and the role of serpin-6 in saving cells dramatically -- and explosively -- visible.
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- Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
03-21-2007 · EurekAlert!
Scientists have found a gene mutation that can dramatically reduce the number of colon polyps that develop, potentially cutting the risk of cancer. Researchers studying mice prone to develop polyps discovered that animals carrying the damaged gene had about 90 percent fewer polyps in the small intestine and colon. Because people with large numbers of polyps are at higher risk for colon cancer, the finding may provide new ways to diagnose, prevent and treat it.
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- Jefferson scientists find aging gene also protects against prostate cancer development
11-27-2006 · EurekAlert!
Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.
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