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X-ray evidence supports possible new class of supernova

01-05-2007 · European Space Agency (ESA)

Evidence for a significant new class of supernova has been found with the European Space Agency's XMM-Newton and NASA's Chandra X-ray Observatory. These results strengthen the case for a population of stars that evolve rapidly and are destroyed by thermonuclear explosions. Such 'prompt' supernovas could be valuable tools for probing the early history of the cosmos.

Keywords: x-ray, evidence, supports, possible, class, supernova, ray, support

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X-ray evidence supports possible new class of supernova
01-04-2007 · EurekAlert!
Evidence for a significant new class of supernova has been found with NASA's Chandra X-ray Observatory and the European Space Agency's XMM-Newton. These results strengthen the case for a population of stars that evolve rapidly and are destroyed by thermonuclear explosions. Such "prompt" supernovas could be valuable tools for probing the early history of the cosmos.
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Rare example of Darwinism seen in action
07-31-2007 · EurekAlert!
A research team, including UC Riverside biologists, has found experimental evidence that supports a controversial theory of genetic conflict in the reproduction of those animals that support their developing offspring through a placenta. The conflict has been likened to a "battle of the sexes" or an "arms race" at the molecular level between mothers and fathers. At stake: the fetus's growth rate and how much that costs the nutrient-supplying mother.
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Possible progenitor of special supernova type detected
02-13-2008 · EurekAlert!
Using data from NASA's Chandra X-ray Observatory, scientists have reported the possible detection of a binary star system that was later destroyed in a supernova explosion. The new method they used provides great future promise for finding the detailed origin of these important cosmic events.
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Advance in understanding of blood pressure gene could lead to new treatments
02-04-2007 · EurekAlert!
Research by scientists at UCL (University College London) has clearly demonstrated for the first time the structure and function of a gene crucial to the regulation of blood pressure. The discovery could be important in the search for new treatments for illnesses such as heart disease, the UK's biggest killer. In a paper published online today in Nature Medicine, the team, led by Professor Patrick Vallance and Dr James Leiper, UCL Department of Medicine, reveal the role of the human gene dimethylarginine dimethylaminohydrolase (DDAH), showing that loss of DDAH activity disrupts nitric oxide (NO) production. NO is critical in the regulation of blood pressure, nervous system functions and the immune system. The role of DDAH is to break down modified amino acids (Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA)) that are produced by the body and have been shown to inhibit NO synthase. These molecules accumulate in various disease states including diabetes, renal failure and pulmonary and systemic hypertension, and their concentration in plasma (the fluid component of blood) is strongly predicative of cardiovascular disease and death. In a healthy human body, the majority of ADMA is eliminated through active metabolism by DDAH. Scientists have hypothesised that if DDAH function is impaired, NO production is reduced, and that this could be an important feature of increased cardiovascular risk. To examine this pathway in more detail, the researchers deleted the DDAH gene in mice. These mice went on to develop hypertension, or high blood pressure. They also designed specific inhibitors (small molecules) which bind to the active site of human DDAH. These small molecule inhibitors also induced hypertension in mice, confirming the importance of DDAH in the regulation of blood pressure. Dr Leiper, UCL Medicine, said: “These genetic and chemical approaches to disrupt DDAH showed remarkably consistent results, and provide compelling evidence that loss of DDAH function increases the concentration of ADMA and thereby disrupts vascular NO signalling. “There has been considerable scientific interest in this pathway and the role of ADMA as a novel risk factor, but so far there's been little evidence to support the idea that it's a cause of disease, rather than just a marker. Genes and their pathways are crucial to our understanding of cardiovascular disease and a better understanding of DDAH-1 could lead to important new treatments. “It could help us to establish if genetic variation predisposes certain people to these diseases, or whether environmental factors exert some of their effects through modulation of DDAH activity. “Our research also shows that this pathway could be harnessed therapeutically to limit production of NO in certain situations where too much nitric oxide is a bad thing; for example, hypotension and septic shock. These are some of the biggest problems in intensive care medicine and there is a huge unmet need for drug treatments.” The study, which was carried out at UCL's Rayne Institute, was funded by grants from the British Heart Foundation, the Wellcome Trust and the Medical Research Council. Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, said: "The unexpected finding in the 1980s that a simple gas, nitric oxide (NO), is made by cells in the blood vessel wall and is a powerful control of blood vessel relaxation led to the award of the Nobel Prize in 1998 to its discoverers. "More recently, there has been increasing evidence that impairment of NO production is likely to be an important factor in the development of heart and circulatory disease, but the mechanisms responsible are not fully understood. "This study suggests for the first time that the loss of the activity of the enzyme DDAH-1 leads to reduced NO production and may cause heart and circulatory disease. These findings are likely to be important in the search for new ways to optimise the health of our blood vessels." ### Notes for Editors 1. For more information, please contact Ruth Metcalfe in the UCL Media Relations Office on tel: +44 (0)20 7679 9739, mobile: +44 (0)7990 675 947, out of hours: +44 (0)7917 271 364, e-mail: r.metcalfe@ucl.ac.uk2. 'Disruption of methylarginine metabolism impairs vascular homeostasis' is published in the February issue of the journal Nature Medicine. Advance online publication is embargoed to 18.00 GMT (13.00 US Eastern) Sunday 4 February 2007. Journalists can obtain copies of the paper by contacting the UCL Media Relations Office.3. The study was funded by the British Heart Foundation, the Wellcome Trust and the Medical Research Council. About UCL Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. In the government's most recent Research Assessment Exercise, 59 UCL departments achieved top ratings of 5* and 5, indicating research quality of international excellence. UCL is the fourth-ranked UK university in the 2006 league table of the top 500 world universities produced by the Shanghai Jiao Tong University. UCL alumni include Mahatma Gandhi (Laws 1889, Indian political and spiritual leader); Jonathan Dimbleby (Philosophy 1969, writer and television presenter); Junichiro Koizumi (Economics 1969, Prime Minister of Japan); Lord Woolf (Laws 1954, Lord Chief Justice of England & Wales); Alexander Graham Bell (Phonetics 1860s, inventor of the telephone), and members of the band Coldplay.
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Modeling lung cancer
02-12-2007 · EurekAlert!
In a new report in the February 15 issue of G&D, Dr. Martin McMahon and colleagues present a novel mouse model of non-small cell lung cancer, which will serve as a useful tool to test the efficacy of novel chemotherapeutic drug therapies in the early stages of lung tumorigenesis. Their paper provides evidence to support the use of a relatively new class of drugs, called MEK inhibitors, for lung cancer patients whose tumors contain mutations in the BRaf gene.
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The gobbling dwarf that exploded
07-13-2007 · EurekAlert!
A unique set of observations, obtained with ESO's VLT, has allowed astronomers to find direct evidence for the material that surrounded a star before it exploded as a Type Ia supernova. This strongly supports the scenario in which the explosion occurred in a system where a white dwarf is fed by a red giant.
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XMM-Newton reveals a magnetic surprise
02-22-2007 · European Space Agency (ESA)
ESA's X-ray observatory XMM-Newton has revealed evidence for a magnetic field in space where astronomers never expected to find one. The magnetic field surrounds a young star called AB Aurigae and provides a possible solution to a twenty-year-old puzzle.
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NASA images, White Sands features support a wetter Mars
12-07-2006 · EurekAlert!
NASA's announcement yesterday of evidence that water still flows on Mars, at least in brief spurts, demonstrates that the view of Mars as a very dry planet should be re-evaluated, says Dawn Sumner, professor of geology at UC Davis. Recent work from by Sumner and graduate student Greg Chavdarian also supports the presence of liquid water near the surface.
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New research disproves belief that group psychotherapy extends the lives of cancer patients
05-01-2007 · EurekAlert!
Previously-published research has given credence to the notion that psychotherapy extends the lives of people with cancer. In fact, one in four cancer patients believe that science supports the idea that participating in group therapy will extend their lives. However, researchers as the University of Pennsylvania School of Medicine concluded -- after an extensive research review -- that there is no compelling evidence linking psychotherapy or support groups with survival among cancer patients.
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New links in the cystic fibrosis chain uncover potential therapeutics
10-18-2007 · EurekAlert!
Cystic fibrosis is an inherited disease caused by mutations in the CFTR gene. Each mutation has number of effects on lung cells. New in vitro evidence published in the Journal of Clinical Investigation has provided insight into the mechanisms by which one of these changes impacts both CF and the complications of CF, providing support for ongoing clinical trials and raising the possibility of new targets for the development of drugs to treat CF.
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