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Tumor-suppressor gene is critical for placenta development
01-09-2007 · EurekAlert!An important cancer-related gene may play a critical role in the development of the placenta, the organ that controls nutrient and oxygen exchange between a mother and her fetus during pregnancy, and perhaps in miscarriages. Those conclusions come from a new study of the retinoblastoma (Rb) gene in mice. In humans, this gene, when mutated, raises the risk of a rare cancer of the eye called retinoblastoma.
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Keywords: tumor-suppressor, gene, critical, placenta, development, tumor, suppressor
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- New function for colon cancer gene found
01-17-2008 · EurekAlert!
Dartmouth Medical School geneticists have discovered a striking turnabout role for a gatekeeper known to put on the brakes for colon cancer. Flaws in a gene called adenomatous polyposis coli, which normally prevents excessive cell growth, are thought to trigger development of most colorectal cancers. But in an about face, the tumor suppressor gene also has a second task, the researchers found, as a gas pedal that accelerates signaling between cells.
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- Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
11-01-2006 · EurekAlert!
Cell biologists have provided further evidence that a gene thought to play a role in suppressing tumors actually protects against the development of pre-cancerous cell growth as well. The researchers say that the gene, caveolin-1, which they found in two major types of breast cells, could be a potential target for future drugs aimed at preventing breast cancer. The work also suggests a potentially important role of the tumor "microenvironment" in the cancerous process.
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- Cold Spring Harbor Laboratory scientists discover new gene that prevents multiple types of cancer
02-09-2007 · EurekAlert!
A decades-old cancer mystery has been solved by researchers at Cold Spring Harbor Laboratory (CSHL). "We not only found a critical tumor suppressor gene, but have revealed a master switch for a tumor suppressive network that means more targeted and effective cancer therapy in the future," said CSHL Associate Professor Alea Mills, Ph.D. The study, headed by Mills, was published in the February issue of Cell.
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- Gene found to play a suppressor role in skin cancer development
02-06-2008 · EurekAlert!
Researchers at the Burnham Institute for Medical Research have provided genetic evidence that Activating Transcription Factor 2 plays a suppressor role in skin cancer development. ATF2 is a protein that regulates gene transcription, the first step in the translation of genetic code, in response to extracellular stresses such as ultraviolet light and ionizing radiation. This function of ATF2 in stress and DNA damage response suggests it may also play a role in tumor formation.
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- Pioneering study looks at p53’s Role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
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- Defects in critical gene lead to accelerated lung tumor growth
08-05-2007 · EurekAlert!
Scientists at the University of North Carolina at Chapel Hill School of Medicine and Harvard Medical School have found that a mutated tumor suppressor gene, LKB1, may result in lung tumors that are more aggressive and more likely to spread throughout the body.
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- Pioneering study looks at p53's role in tumor-stroma interactions
10-25-2006 · EurekAlert!
Researchers have conducted the first comprehensive study of the role an important tumor suppressor gene plays in cancer development. P53 is known as a major tumor suppressor that is frequently mutated in human cancer. In this study, researchers used novel proteomic techniques to identify the proteins secreted by cells specifically in response to p53. The findings suggest a newfound role for wt-p53 in the control of the tumor's ability to communicate with the normal stromal cells surrounding it.
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- Multicenter study nets new lung tumor-suppressor gene
08-05-2007 · EurekAlert!
Collaborating scientists in Boston and North Carolina have found that a particular gene can block key steps of the lung cancer process in mice. The researchers report in the journal Nature that LKB1 is not only a "tumor-suppressor" gene for nonsmall cell lung cancer in mice, it also may be more powerful than other, better-known suppressors. The study will be published on the journal's Web site on Aug. 5.
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- The genetics of MLL leukemogenesis
10-16-2007 · EurekAlert!
In the Nov. 1 issue of G&D, Dr. Michael Cleary and colleagues identify the gene Meis1 as a critical player in the establishment of leukemia stem cells, and the development of MLL leukemia.
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- Small molecule dervived from Rb2/p130 could act as cancer therapeutic
03-20-2007 · EurekAlert!
A small molecule derived from the spacer domain of the tumor-suppressor gene Rb2/p130 has demonstrated the ability to inhibit tumor growth in vivo and could be developed into an anti-cancer therapeutic, according to researchers at Temple University's Sbarro Institute for Cancer Research and Molecular Medicine.
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