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Waste not, want not: Role for caveolin-3 in muscular dystrophy
10-12-2006 · EurekAlert!Muscular dystrophies are characterized by skeletal muscle weakness due to muscle fiber wasting and loss. Kawasaki Medical School researchers now show in the JCI that mice lacking caveolin-3 -- a protein that helps form a scaffold onto which other signaling molecules assemble at the cell plasma membrane -- increases the intracellular activity of myostatin, an inhibitor of muscle growth, and leads to muscle wasting. Myostatin inhibition may have potential as a therapy for certain muscular dystrophies.
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Keywords: waste, want, role, caveolin-3, muscular, dystrophy, caveolin
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This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, Oct. 12, 2006, in the JCI, including: Waste not, want not: Role for caveolin-3 in muscular dystrophy; Elevated PTTG1 levels trigger mitotic mischief, causing thyroid cancer; NF-kappaB2 teaches tolerance; and Type I IFNs beat IFN-gamma to the immunoproteasome.
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