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Targeting tau: Inflammation study suggests new approach for fighting Alzheimer's
02-01-2007 · EurekAlert!Researchers at the University of Pennsylvania School of Medicine have shown that impaired function and loss of synapses in the hippocampus of a mouse form of Alzheimer's disease (AD) is related to the activation of immune cells called microglia, which cause inflammation. These events precede the formation of tangles -- twisted fibers of tau protein that build up inside nerve cells -- a hallmark of advanced AD.
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Keywords: targeting, tau, inflammation, study, suggests, approach, fighting, alzheimer, suggest
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- Researchers find new way to block destructive rush of immune cells
01-14-2008 · EurekAlert!
Researchers have found a way to selectively block the ability of white blood cells to "crawl" toward the sites of injury and infection when such mobility drives disease, according to a study published today in the Journal of Experimental Medicine. The results suggest a new treatment approach for autoimmune diseases like rheumatoid arthritis, lupus and multiple sclerosis, and for conditions made worse by misplaced inflammation, like atherosclerosis, stroke and transplant rejection, researchers said.
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- Antioxidants decrease disease in a Drosophila model of Alzheimer's disease
12-14-2006 · EurekAlert!
Alzheimer's disease (AD) is a neurodegenerative disorder in which brain cells damaged by naturally occurring chemicals known as reactive oxygen species have been observed. Whether this oxidative damage causes neurodegeneration or is a consequence of it has not been previously determined. A study now indicates that oxidative damage contributes to neurodegeneration in a Drosophila model of disorders such as AD, suggesting that targeting antioxidant pathways might provide a new approach for treating individuals with AD.
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- Study questions 'one size fits all' approach when measuring income's effect on school readiness
02-07-2007 · EurekAlert!
Findings from an analysis of the Early Childhood Longitudinal Study suggest that race and ethnic identity should influence the approach used to measure the socio-emotional and pre-academic skills that contribute to school readiness. The ECLS is a nationally representative sample of over 21,000 Kindergarteners. The research suggests that the "one size fits all approach" used to measure parenting and stressors that relate to poverty and school readiness should be reconsidered.
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- Specific antagonism lowers blood pressure
08-16-2007 · EurekAlert!
High blood pressure is associated with an increased risk of heart attack and stroke. A new study in the Journal of Clinical Investigation now shows that antagonists of a receptor known as EP1 reduce hypertension in mice and rats. The authors therefore suggest that targeting the PGE2 receptor EP1 might be a viable approach to treating hypertension.
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- USC-led study suggests exercise reduces risk of developing invasive breast cancer
02-26-2007 · EurekAlert!
Significant findings have emerged from the California Teachers Study (CTS) that suggest long-term recreational physical activity plays a protective role against invasive and in situ breast cancer.
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- For treating advanced Parkinson's, new research points to serotonin
02-04-2008 · EurekAlert!
Studies in a mouse model of Parkinson's disease show that side effects caused by repeated use of the drug L-DOPA can be minimized by blocking the serotonin 1B receptor. The finding, reported by researchers at Rockefeller University and the Karolinska Institute, suggests that targeting the 1B receptor may provide an alternative approach for treating advanced Parkinson's disease.
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- Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
10-19-2006 · EurekAlert!
Rheumatoid arthritis (RA) is caused by the immune system inappropriately attacking the joints. The autoimmune response also leads to the recruitment and/or differentiation of cells known as osteoclasts -- cells that degrade and resorb bone. Current treatments for RA target either the joint-specific immune response or the osteoclast-mediated bone erosion but a new study suggests that targeting a protein known as PLC-gamma-2 might lead to control of both immune-mediated joint destruction and osteoclast-mediated bone erosion.
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- Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
08-08-2007 · EurekAlert!
At menopause, women lose hormone protection against heart and kidney diseases, and are likely to become obese. A research team has tested the idea that estrogen deficiency in aged females may trigger the development of high blood pressure and obesity. The results of their study, using an animal model, suggest that estrogen depletion can have these effects.
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- Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
08-21-2007 · EurekAlert!
Scientists at the University of Toronto Mississauga and Queen's University show that genetic variation in the foraging gene results in different tolerance for heat stress and demonstrate how the use of specific drugs can replicate this effect in fruit flies and locusts. While the findings are at an early stage, the researchers suggest that they could lead to ways to rapidly protect the brain from extremely high fevers in mammals, including humans.
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- New study suggests cause of debilitating skin condition
09-24-2007 · EurekAlert!
New findings from researchers at Wake Forest University Baptist Medical Center and colleagues suggest why some people with kidney failure can develop a rare tightening and swelling of the skin and other organs, including the lungs and heart.
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