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Sentry enzyme blocks two paths to Parkinson's disease
02-01-2007 · EurekAlert!The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse models by investigators at St. Jude Children's Research Hospital.
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Keywords: sentry, enzyme, blocks, paths, parkinson, disease, block, path
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- Jefferson scientists find aging gene also protects against prostate cancer development
11-27-2006 · EurekAlert!
Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.
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- Cough medicine fights dyskinesias in Parkinson's
11-07-2007 · EurekAlert!
A cough suppressant and a drug tested against schizophrenia curb dyskinesias, the involuntary movements that are disabling side effects of taking the Parkinson's disease medication levodopa, Portland scientists found. Dextromethorphan, used in such cold and flu medications as Robitussin and Sucrets, suppresses dyskinesias in rats. BMY-14802, a drug tested in people with schizophrenia, also suppresses dyskinesias in rats, and does so more effectively than dextromethorphan, suggesting BMY-14802 might block dyskinesias in people with Parkinson's.
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- Alzheimer's-associated enzyme can disrupt neural activity in the brain
06-17-2007 · EurekAlert!
An enzyme involved in the formation of the amyloid-beta protein associated with Alzheimer's disease can also alter the mechanism by which signals are transmitted between brain cells, the disruption of which can cause seizures. These findings from researchers at the MassGeneral Institute for Neurodegenerative Disorders may explain the increased incidence of seizures in Alzheimer's patients, and suggest that potential treatments that block this enzyme may alleviate their occurrence
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- Researchers discover surprising drug that blocks malaria
01-15-2007 · EurekAlert!
Northwestern University researchers have uncovered how malaria parasites break into red blood cells and how to block the invading parasites with a commonly prescribed high-blood pressure medication. This opens the door for important new drugs to which the parasites are much less likely to become resistant. Malaria is surging worldwide because of drug resistance and the lack of an effective vaccine. Jamaica, which had eradicated the disease for 50 years, recently reported an outbreak.
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- New player in commitment to life as a fat cell
02-06-2007 · EurekAlert!
Researchers have discovered a pivotal new player in early events that commit fat cell precursors to becoming full-blown fat, according to a report in the February issue of the journal Cell Metabolism, published by Cell Press. Drugs that block some activities of the enzyme, known as xanthine oxidoreductase (XOR), might therefore offer a novel antiobesity therapy designed to fight fat before it even forms, the researchers said.
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- Molecular mechanism of common forms of kidney disease identified
08-01-2007 · EurekAlert!
Massachusetts General Hospital researchers have identified a key mechanism underlying proteinuria -- excess protein in the urine which signifies a breakdown in the kidney's filtering process. They have discovered that enzymatic processing of protein called dynamin can cause breakdown of a critical filtering structure called a podocyte, allowing protein to leak out of the bloodstream. The researchers also describe how altered forms of dynamin may be able to block the process and restore kidney function.
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- Cholesterol byproduct blocks heart health benefits of estrogen
09-16-2007 · EurekAlert!
New findings by UT Southwestern Medical Center researchers show that a byproduct of cholesterol metabolism interferes with the beneficial effects estrogen has on the cardiovascular system, providing a better understanding of the interplay between cholesterol and estrogen in heart disease.
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- Drug improves tremors, involuntary movements in Parkinson patients
01-01-2007 · EurekAlert!
A drug used to treat epilepsy has been found to significantly improve tremors, motor fluctuations and other involuntary movements, or dyskinesias, in patients with Parkinson disease, according to a study published in the Jan. 2, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology.
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- Find yields further insight into causes of Parkinson's disease
02-01-2007 · EurekAlert!
In the fruit fly Drosophila, the mutated parkin gene causes motor dysfunction and may be key to understanding the cause of familial Parkinson's in humans.
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- Enhancing activity of marijuana-like chemicals in brain helps treat
02-07-2007 · EurekAlert!
Marijuana-like chemicals in the brain may point to a treatment for the debilitating condition of Parkinson's disease.
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