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Carnegie Mellon researcher proposes development of artificial cells to fight disease
02-07-2007 · EurekAlert!Carnegie Mellon University's Philip Leduc predicts the use of artificially created cells could be a potential new therapeutic approach for treating diseases in an ever-changing world.
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- Discovery of an HIV inhibitor in human blood points to new drug class
04-19-2007 · EurekAlert!
A new study has pinpointed a natural ingredient of human blood that effectively blocks HIV-1, the virus predominantly responsible for human AIDS, from infecting immune cells and multiplying. The virus blocker might play a role in the progression of HIV to full-blown AIDS and -- because it works in a different way than existing antiretroviral inhibitors -- could lead to the development of another class of drugs in the fight against the pandemic disease.
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- Weizmann Institute scientists discover genes that can slow cell division and may fight cancer
02-26-2007 · EurekAlert!
When cells begin to divide, they also activate a "braking system" that eventually stops cell division. When this system is faulty, uncontrolled cell division and the growth of cancer can result. Weizmann Institute scientists have identified a number of the genes involved in this braking system. Identification of the exact factors causing uncontrolled cell division may lead to the development of advanced treatments for cancer.
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- Anthrax cellular entry point uncovered
01-25-2008 · EurekAlert!
Anthrax spores enter the cell through something called Mac-1, a receptor that sits on the surface of certain cells, according to a new study. Unraveling the anthrax-Mac-1 gateway will speed the development of new drugs and vaccines to fight or prevent infection, and advance the understanding of bacterial infection. The study was the work of microbiologists at the University of Alabama at Birmingham.
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- Jefferson scientists find aging gene also protects against prostate cancer development
11-27-2006 · EurekAlert!
Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.
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- Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
07-25-2007 · EurekAlert!
Carnegie Mellon University scientists have made an important discovery that helps to explain why HIV enters immune cells with ease. They found that after HIV docks onto a host cell, it dramatically lowers the energy required for a cell membrane to bend, making it easier for the virus to infect immune cells. The finding will provide vital data to conduct future computer simulations of HIV dynamics to help further drug discovery and prevent deadly infections.
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- Reprogrammed human adult stem cells rescue diseased muscle in mice
12-12-2007 · EurekAlert!
Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease. The research, published by Cell Press in the December issue of Cell Stem Cell, represents a significant advance toward the future development of a gene therapy that uses a patient's own cells to treat this devastating muscle-wasting disease.
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- JCI table of contents -- May 17, 2007
05-17-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, May 17, 2007, in the JCI, including: Role of TRPM8 in the development of prostate cancer; Blocking aggrecanase-2 activity prevents cartilage erosion in arthritis; Keeping red blood cells hydrated in sickle cell disease; Enzymes and exercise curb muscle insulin resistance; Endothelial progenitor cells mend vessel damage with a little help from EphB4; and others.
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- Stem cells show promise for treating Huntington's disease
09-25-2007 · EurekAlert!
Paying close attention to how a canary learns a new song has helped scientists open a new avenue of research against Huntington's disease -- a fatal disorder for which there is currently no cure or even a treatment to slow the disease. Scientists used gene therapy to guide the development of endogenous stem cells in the brains of mice affected by a form of Huntington’s, generating new medium spiny neurons -- the cell lost in Huntington's disease.
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- UCSD researchers discover inflammation, not obesity, cause of insulin resistance
11-06-2007 · EurekAlert!
Researchers at the University of California, San Diego School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and type 2 diabetes. Their discovery may pave the way to novel drug development to fight the epidemic of type 2 diabetes associated with obesity, the most prevalent metabolic disease worldwide.
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- Red alert: Wild strawberries may reduce cancer risk
12-02-2007 · EurekAlert!
We've all seen the term "super food" used to describe those nutrition-loaded edibles that promote health and discourage disease. Powerhouse foods high in antioxidants and phytochemicals that block the development of cancer cells have been touted as nature's way to fight off the potentially devastating disease.
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