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Disrupting brain's stress system intensifies opiate withdrawal

Avoiding the severe pain, nausea, agitation, sweats and other symptoms of opiate withdrawal are among the many reasons addicts are motivated to continue taking drugs. Now, researchers have found that disrupting the brain's stress-response mechanism exacerbates behavioral withdrawal symptoms in mice, and that giving the mice the hormone corticosterone alleviates those symptoms. The researchers said their findings suggest new approaches to reduce withdrawal symptoms.

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Keywords: disrupting, brain, stress, system, intensifies, opiate, withdrawal, intensify

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