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Protein inhibitor tangles with Alzheimer's disease

A hallmark of Alzheimer's disease (AD) is the abnormal accumulation of phosphorylated forms of a protein known as tau. In a new study, Mayo Clinic researchers have now shown in mice that a drug that inhibits the function of the protein Hsp90 (EC102) reduces the amount of phosphorylated tau in the brain. Unlike many drugs, EC102 is able to cross the blood-brain barrier, making it a highly promising therapeutic candidate for AD.

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Keywords: protein, inhibitor, tangles, alzheimer, disease, tangle

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1. JCI table of contents: February 15, 2006
   02-15-2007 · EurekAlert!
   This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, February 15, 2006, in the JCI, including: Protein inhibitor tangles with Alzheimer's disease; Proteases cause pain in irritable bowel syndrome; The "shear stress" of it impacts heart disease; Blood pressure heads down in the absence of PPAR-gamma; and Profiling peripheral T cell lymphoma for clues to its pathogenesis.
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2. Targeting tau: Inflammation study suggests new approach for fighting Alzheimer's
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3. Vaccine thwarts the tangles of Alzheimer's
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10. Bad Alzheimer's proteins sow disorder in the brain
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