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Penn researchers replace organ in adult mice using 'single-parent' stem cells
02-16-2007 · EurekAlert!Single-parent stem cells can proliferate normally in an adult organ and could provide a less controversial alternative to the therapeutic cloning of embryonic stem cells.
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Keywords: penn, researchers, replace, organ, adult, mice, single-parent, stem, cells, researcher, single, parent, cell
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- U of MN adult stem cell research shows promise for transplant therapies
01-15-2007 · EurekAlert!
University of Minnesota stem cell researchers, together with collaborators at Stanford University, have successfully used adult stem cells to replace the immune system and bone marrow of mice, offering the promise of new therapies for people in the future.
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- Cloned Mice Created From Fully Differentiated Cells, A Milestone In Cloning Research
10-02-2006 · ScienceDaily
New research dismisses the notion that adult stem cells are necessary for successful animal cloning, proving instead that cells that have completely evolved to a specific type not only can be used for cloning purposes, but they may be better and more efficient. As proof, researchers report they created two mouse pups from a type of blood cell that itself is incapable of dividing to produce a second generation of its own kind.
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- Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
11-22-2007 · EurekAlert!
Researchers at the Stanford University School of Medicine have taken a small but significant step, in mouse studies, toward the goal of transplanting adult stem cells to create a new immune system for people with autoimmune or genetic blood diseases.
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- Penn Veterinary Medicine report new strategy to create genetically-modified animals
09-20-2007 · EurekAlert!
Researchers at Penn Vet have demonstrated a new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring. Scientists at the Center for Animal Transgenesis and Germ Cell Research at Penn introduced adeno-associated virus to germline stem cells in goats and mice. AAV stably transduced male germ line stem cells and led to transgene transmission through the male germ line.
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- Loss of stem cells correlates with premature aging in animal study
06-06-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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- Penn Veterinary Medicine report new strategy to create genetically modified animals
09-20-2007 · EurekAlert!
Researchers at Penn Vet have demonstrated a new strategy for genetic modification of large animals by employing a virus that transfers genetic modifications to male reproductive cells, which passes naturally to offspring. Scientists at the Center for Animal Transgenesis and Germ Cell Research at Penn introduced adeno-associated virus to germline stem cells in goats and mice. AAV stably transduced male germ line stem cells and led to transgene transmission through the male germ line.
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- Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
12-10-2006 · EurekAlert!
A team of researchers from Carnegie Mellon University and the University of Pittsburgh has created and used an innovative ink-jet system to print "bio-ink" patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells. The results, which could revolutionize the design of replacement body tissues, will be presented Sunday, Dec. 10 at the 46th annual meeting of the American Society for Cell Biology in San Diego.
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- Mice cloned from skin cells
02-12-2007 · EurekAlert!
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells. The scientists used keratinocyte stem cells, which represent a new model system for cloning. Keratinocytes come from the skin, making them a particularly attractive stem cell source because of their ready accessibility. One day, they could be used to tailor therapies, as well as to better understand and treat diseases.
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- Simple recipe turns human skin cells into embryonic stem cell-like cells
11-20-2007 · EurekAlert!
A simple recipe -- including just four ingredients -- can transform adult human skin cells into cells that resemble embryonic stem cells, researchers report in an immediate early publication of the journal Cell, a publication of Cell Press. The converted cells have many of the physical, growth and genetic features typically found in embryonic stem cells and can differentiate to produce other tissue types, including neurons and heart tissue, according to the researchers.
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- Human embryonic stem cell -- derived bone tissue closes massive skull injury
12-02-2007 · EurekAlert!
There are mice in Baltimore whose skulls were made whole again by bone tissue grown from human embryonic stem cells. Healing critical-size defects, which would not otherwise heal on their own, in intramembraneous bone, the flat bone type that forms the skull, is a vivid demonstration of new techniques devised by researchers using hESCs for tissue regeneration.
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