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Gene hunters close in on Lou Gehrig’s disease

In the first genome-wide search for the genetic roots of the most common form of amyotrophic lateral sclerosis (ALS), Johns Hopkins scientists have newly identified 34 unique variations in the human genetic code among 276 unrelated subjects with ALS.

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Keywords: gene, hunters, close, lou, gehrig, disease, hunter

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1. Cancer researchers add spice to research against rare neuromuscular disease
   03-20-2007 · EurekAlert!
   Scientists have discovered a compound that shows promise against a debilitating neurodegenerative condition known as Kennedy's disease, which is caused by a mutant gene. Currently there is no treatment for the inherited disorder, which resembles a slowly progressive form of Lou Gehrig's disease and affects mainly men.
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2. Diseased brain cells more involved in ALS-associated motor neuron death
   04-15-2007 · EurekAlert!
   Two papers by Columbia and Harvard researchers report for the first time that astrocytes -- the most abundant non-neuronal cells in the central nervous system, which carry a mutated gene known to cause some cases of amyotrophic lateral sclerosis (ALS/Lou Gehrig's disease) -- induce motor neuron death. This indicates that astrocytes may contribute to ALS by releasing a toxic factor that damages neurons.
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3. UCLA, Italian chemists move closer to solving Lou Gehrig's disease mystery
   06-27-2007 · EurekAlert!
   Chemists from UCLA and the University of Florence in Italy may have solved an important mystery about a protein that plays a key role in a particular form of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. If scientists can figure out why ALS patients do not have copper or zinc in the protein, that would be a major advance that could lead to treatment.
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4. Stem cell therapy rescues motor neurons in ALS model
   07-31-2007 · EurekAlert!
   In a study that demonstrates the promise of cell-based therapies for diseases that have proved intractable to modern medicine, a team of scientists from the University of Wisconsin-Madison has shown it is possible to rescue the dying neurons characteristic of amyotrophic lateral sclerosis, a fatal neuromuscular disorder also known as Lou Gehrig's disease.
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5. Findings suggest current approach to drug discovery for Lou Gehrig's disease be re-examined
   05-07-2007 · EurekAlert!
   Most research on Lou Gehrig's disease therapeutics has been based on the assumption that its two forms (sporadic and hereditary) are similar in their underlying cause. Now, researchers at the University of Pennsylvania School of Medicine have found an absolute biochemical distinction between these two disease variants, suggesting that current approaches to drug discovery should be re-examined.
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6. Human stem cells delay start of Lou Gehrig's disease in rats
   10-15-2006 · EurekAlert!
   Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig's, also known as amyotrophic lateral sclerosis (ALS). The study is published in this week's issue of Transplantation.
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7. Damaged motor neurons in ALS contribute to their own death
   04-23-2007 · EurekAlert!
   Researchers from the Ludwig Institute and the University of California, San Diego (UCSD) School of Medicine have discovered that when motor neurons damaged by amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, inappropriately send the wrong signal, immune cells react by killing the messenger. Their surprising finding provides new direction for therapies to treat ALS.
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8. Misfolded Protein Clumps Found To Be Common To Dementia, Lou Gehrig's Disease
   10-06-2006 · ScienceDaily
   Scientists funded by the National Institute on Aging have identified a protein common to two neurodegenerative diseases -- frontotemporal dementia and Lou Gehrig's disease. This discovery suggests that these diseases might share a common pathological process.
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9. Research suggests new direction for ALS treatment
   11-27-2007 · EurekAlert!
   A research team from Wake Forest University School of Medicine is the first to show that injections of a protein normally found in human cells can increase lifespan and delay the onset of symptoms in mice with ALS, or Lou Gehrig's disease.
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10. JCI table of contents: Jan. 24, 2008
    01-24-2008 · EurekAlert!
    This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published Jan. 24, 2008, in the JCI: TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks; Building stronger bones, one stem cell at a time; Understanding a cause of Lou Gehrig’s disease; Genetic link to one form of a very common pediatric illness; and I can see clearly now Epo has come and gone.
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