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Cloned Mice Created From Fully Differentiated Cells, A Milestone In Cloning Research
10-02-2006 · ScienceDailyNew research dismisses the notion that adult stem cells are necessary for successful animal cloning, proving instead that cells that have completely evolved to a specific type not only can be used for cloning purposes, but they may be better and more efficient. As proof, researchers report they created two mouse pups from a type of blood cell that itself is incapable of dividing to produce a second generation of its own kind.
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Keywords: cloned, mice, created, fully, differentiated, cells, milestone, cloning, research, cell
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- Mass. General researchers identify master cardiac stem cell
11-22-2006 · EurekAlert!
Researchers from the Massachusetts General Hospital Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major cell types of the mammalian heart. In a report to appear in the journal Cell, receiving early online release, they describe identifying these progenitor cells in mice, cloning them from embryonic stem cells, and showing that cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.
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- Mice cloned from skin cells
02-12-2007 · EurekAlert!
Healthy and viable mice that survive until adulthood have, for the first time, been cloned from adult stem cells. The scientists used keratinocyte stem cells, which represent a new model system for cloning. Keratinocytes come from the skin, making them a particularly attractive stem cell source because of their ready accessibility. One day, they could be used to tailor therapies, as well as to better understand and treat diseases.
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- Pittsburgh-based team engineers muscle, bone cell differentiation with aid of ink-jet printer
12-10-2006 · EurekAlert!
A team of researchers from Carnegie Mellon University and the University of Pittsburgh has created and used an innovative ink-jet system to print "bio-ink" patterns that direct muscle-derived stem cells from adult mice to differentiate into both muscle cells and bone cells. The results, which could revolutionize the design of replacement body tissues, will be presented Sunday, Dec. 10 at the 46th annual meeting of the American Society for Cell Biology in San Diego.
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- Chemical cues turn embryonic stem cells into cerebellar neurons
03-14-2007 · EurekAlert!
Rockefeller University scientists show that embryonic stem cells implanted in the brain appear to develop into fully differentiated granule neurons, the most plentiful neuron in the cerebellum. The findings are a step toward understanding how embryonic stem cells could be regulated in vivo and ultimately used for cell replacement therapy, especially after childhood tumors, in the central nervous system.
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- New hope for regenerative medicine
02-14-2007 · EurekAlert!
In the February 15th issue of Genes & Development, Dr. K. John McLaughlin and colleagues report on their success in using uniparental embryonic stem cells to replace blood stem cells in mice. Uniparental embryonic stem cells are an appealing alternative source of patient-derived embryonic stem cells, as they have several advantages over embryonic stem cell lines generated by somatic cell nuclear transfer (also known as therapeutic cloning).
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- Brown scientists take the petri dish to new dimensions
09-19-2007 · EurekAlert!
Brown University biomedical engineers have created a new method for growing cells in three dimensions rather than the traditional two. This 3-D petri dish allows cells to self-assemble, creating cell clusters that can be transplanted in the body or used to test drugs in the lab. This simple new technique is part of a growing body of research that shows that 3-D culture techniques can create cells that behave more like cells in the body.
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- Researchers safely regenerate failing mouse hearts with programmed embryonic stem cells
02-27-2007 · EurekAlert!
Mayo Clinic researchers have safely transplanted cardiac preprogrammed embryonic stem cells into diseased hearts of mice successfully regenerating infarcted heart muscle without precipitating the growth of a cancerous tumor -- which, so far, has impeded successful translation into practice of embryonic stem cell research.
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- Human embryonic stem cell lines created that avoid immune rejection
12-20-2007 · EurekAlert!
In a groundbreaking experiment published in Cloning & Stem Cells, scientists from International Stem Cell Corp. derived four unique embryonic stem cell lines that open the door for the creation of therapeutic cells that will not provoke an immune reaction in large segments of the population. The stem cell lines are "HLA-homozygous," meaning that they have a simple genetic profile in the critical areas of the DNA that code for immune rejection.
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08-13-2007 · EurekAlert!
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- Elusive pancreatic progenitor cells found in mice
01-25-2008 · EurekAlert!
Researchers in Belgium have significantly advanced the discovery of a pancreatic progenitor cell with the capacity to generate new insulin-producing beta cells. If the finding made in mice holds for humans, the newfound progenitor cells may represent "an obvious target for therapeutic regeneration of beta cells in diabetes," the researchers report in the Jan. 25 issue of the research journal Cell, a publication of Cell Press.
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