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Drug blocks lethal motor-neuron disease in mice

02-22-2007 · EurekAlert!

Spinal muscular atrophy (SMA) is a motor-neuron disease caused by mutations in the gene SMN1 that prevent it producing the protein SMN. New research shows that in a lethal mouse model of SMA the drug trichostatin A (TSA), which is a hydroxamic acid HDAC inhibitor, can improve survival and attenuate disease, indicating that hydroxamic acid HDAC inhibitors might be potential therapeutics for the treatment of individuals with SMA.

Keywords: drug, blocks, lethal, motor-neuron, disease, mice, block, motor, neuron

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