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Children with cancer risk fragile bones
02-26-2007 · EurekAlert!Physicians caring for children with cancer should be on the lookout for signs of bone fragility caused by disease and treatment, according to a new report.
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Keywords: children, cancer, risk, fragile, bones, bone
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- Researchers develop criteria to detect bone mass deficiencies in children with chronic diseases
06-06-2007 · EurekAlert!
Pediatricians now have a practical tool to help determine whether children with chronic diseases like Crohn's, juvenile arthritis and anorexia nervosa -- or those undergoing cancer treatment -- are at increased risk for bone mass deficiencies, fracture or osteoporosis as they get older, according to a new study whose lead author is a researcher at Cincinnati Children's Hospital Medical Center.
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- Drugs used to fight cancer-related bone problems boost odds of jaw- or face-bone disease
06-26-2007 · EurekAlert!
Treatment with intravenous bisphosphonates -- drugs used to reduce harm done to bones by cancer or cancer therapy -- increases the risk of jaw or facial bone disease or infection, a large-scale comparative study by researchers at the University of Texas Medical Branch at Galveston (UTMB) has found.
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- Preventing graft-vs.-host disease after bone marrow transplant -- without toxicity
12-11-2006 · EurekAlert!
Most patients undergoing bone-marrow transplant must receive powerful chemotherapy drugs to suppress their immune system and prevent their bodies from rejecting the donated cells. New research shows that this chemotherapy increases the risk for graft-versus-host disease -- but also suggests that this risk can be reduced by replacing a natural antibiotic that's depleted when patients undergo chemotherapy. A multicenter study led by Children's Hospital Boston and the Dana-Farber Cancer Institute is about to test this idea.
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- Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
12-11-2006 · EurekAlert!
Most patients undergoing bone-marrow transplant must receive powerful chemotherapy drugs to suppress their immune system and prevent their bodies from rejecting the donated cells. New research shows that this chemotherapy increases the risk for graft-versus-host disease -- but also suggests that this risk can be reduced by replacing a natural antibiotic that's depleted when patients undergo chemotherapy. A multicenter study led by Children's Hospital Boston and the Dana-Farber Cancer Institute is about to test this idea.
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- Phase II study shows HRPC patients with bone metastases see improved survival with ZD4054
09-25-2007 · EurekAlert!
New Phase II data presented today suggest that ZD4054, a novel compound in development for the treatment of men with hormone-resistant prostate cancer, could offer a promising improvement in overall survival in men with metastatic HRPC who were asymptomatic or mildly symptomatic for pain.1 Patients who received ZD4054 10mg once-daily experienced a 45 percent reduction in the risk of death compared to placebo.
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- Bad to the bone: UD research to shed light on osteoporosis
11-15-2007 · EurekAlert!
Ten million people in the US are estimated to already have bone diseases, and almost 34 million more are estimated to have low bone mass, putting them at increased risk for osteoporosis, according to the National Osteoporosis Foundation. UD scientists are now leading research that will shed light on how osteocytes -- the cells encased inside your bones -- sense external stimuli and communicate with cells on the surface, signaling them to either build more bone or remove existing bone.
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- Malaria and Epstein-Barr virus linked to pediatric cancer in Africa
06-07-2007 · EurekAlert!
Arnaud Chene and colleagues have identified CIDRla as the first microbial protein able to spur a latently EBV-infected cell into active production. Their results suggest that P. falciparum-derived proteins can lead to a direct reactivation of EBV during acute malaria infection, increasing the risk of Burkitt lymphoma development for children living in malaria-endemic areas.
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- Childhood cancer survivors at increased risk of severe health problems as adults
06-26-2007 · EurekAlert!
A substantial proportion of childhood cancer survivors experience serious health problems as young adults, particularly those who received radiation treatment, according to a study in the June 27 issue of JAMA, a theme issue on chronic diseases of children.
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- St. Jude finds risk factors for severe RSV infection in immunocompromised children
02-04-2008 · EurekAlert!
St. Jude Children's Research Hospital investigators and collaborators have shown how to predict if a child who is infected with respiratory syncytial virus while being treated for cancer or another catastrophic disease is at high risk for developing severe infection. The finding will help clinicians improve guidelines for managing these infected children.
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- Certain diseases, birth defects may be linked to failure of protein recycling system
12-20-2007 · EurekAlert!
A group of signaling proteins known as Wnt -- which help build the human body's skin, bone, muscle and other tissues -- depend on a complex delivery and recycling system to ensure their transport to tissue-building cell sites. Failure of this system may be a mechanism of cancer, heart disease or birth defects related to Wnt proteins, according to researchers at Cincinnati Children's Hospital Medical Center.
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