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Genetic repair mechanism clears the way for sealing DNA breaks

Scientists investigating an important DNA-repair enzyme now have a better picture of the final steps of a process that glues together, or ligates, the ends of DNA strands to restore the double helix.

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Keywords: genetic, repair, mechanism, clears, way, sealing, dna, breaks, clear, break

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Similar news on "Genetic repair mechanism clears the way for sealing DNA breaks":

1. New study shows how genetic repair mechanism helps seal DNA breaks
   10-19-2006 · EurekAlert!
   A new study by researchers from the Scripps Research Institute, Lawrence Berkeley National Laboratory, the Washington University School of Medicine and the University of Maryland has provided a clearer picture of the final steps of a critical DNA repair process. When these repair processes go awry, cells can malfunction, die or become cancerous.
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2. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
   05-10-2007 · EurekAlert!
   Peter Baumann, Ph.D., assistant investigator, and Nancy Bae, Ph.D., postdoctoral research associate in the Baumann Lab, have published a paper offering insight into the way cells protect chromosome ends from misguided repair.
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3. Unknotting DNA clue to cancer syndrome
   08-02-2007 · EurekAlert!
   A new UC-Davis study that explains the actions of a gene mutation that causes early onset cancer provides a fundamental insight into the mechanism of DNA-break repair.
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4. DNA repair proteins monitored at double-strand break
   05-09-2007 · EurekAlert!
   Investigators at St. Jude Children's Research Hospital had a molecule’s eye view of the human cell’s DNA repair kit as it assembled on a double-strand break to link together the broken ends. Double-strand breaks are ruptures that cut completely across the twisted, ladder-like structure of DNA, breaking it into two pieces.
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5. Age-related changes in DNA repair illuminate the connection between age and genetic damage
   10-23-2006 · EurekAlert!
   Researchers have uncovered a new way in which the aging process is linked to DNA damage -- which occurs normally as a result of cell metabolism and environmental influences -- and the various ways in which cells repair that damage. In the new work, researchers found that cells in young fruit flies make use of a different mix of molecular DNA-repair mechanisms compared to cells in older flies.
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6. Enhanced DNA-repair mechanism can cause breast cancer
   10-15-2007 · EurekAlert!
   Although defects in the "breast cancer gene," BRCA1, have long been known to increase the risk for breast cancer, exactly how the defects lead to tumor growth has remained a mystery. Now scientists provide insight into how the normal BRCA1 gene suppresses the growth of tumors as well as the nature of the genetic instability that leads to cancer when BRCA1 is defective.
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7. Clemson chemists discover new way antioxidants fight debilitating diseases
   08-19-2007 · EurekAlert!
   Debilitating diseases are often linked to DNA damage that occurs when metal ions in the body produce reactive oxygen compounds that damage cells. Studies have shown antioxidants that neutralize this activity and are found in fruits, vegetables, green tea, garlic and onions can be effective at preventing damage. A Clemson team has found a new mechanism for antioxidant activity: antioxidants bind to naturally present iron and copper to prevent formation of compounds that damage DNA.
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8. Nanotechnology meets biology and DNA finds its groove
   02-08-2007 · EurekAlert!
   The object of fascination for most is the DNA molecule. But in solution, DNA, the genetic material that hold the detailed instructions for virtually all life, is a twisted knot, looking more like a battered ball of yarn than the famous double helix. To study it, scientists generally are forced to work with collections of molecules floating in solution, and there is no easy way to precisely single out individual molecules for study.
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9. Genetic material under a magnifying glass
   01-28-2008 · EurekAlert!
   Volker Deckert and his team at the Institute for Analytical Sciences in Dortmund have developed a method that could provide a way to directly sequence DNA by Raman spectroscopy and atomic force microscopy. So far, they have analyzed DNA's closest relative, RNA.
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10. Genome-wide search unearths surprising clues for diabetes and triglycerides
    04-26-2007 · EurekAlert!
    Scientists from the Broad Institute of Harvard and MIT, Lund University and Novartis today announced the discovery of three unsuspected regions of human DNA that contain clear genetic risk factors for type 2 diabetes, and another that is associated with elevated blood triglycerides. The study is among the first to apply a suite of genomic resources to clinical research, including the Human Genome Project, the SNP and HapMap Projects, and genome-scale laboratory and analytical tools.
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