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Researchers safely regenerate failing mouse hearts with programmed embryonic stem cells
02-27-2007 · EurekAlert!Mayo Clinic researchers have safely transplanted cardiac preprogrammed embryonic stem cells into diseased hearts of mice successfully regenerating infarcted heart muscle without precipitating the growth of a cancerous tumor -- which, so far, has impeded successful translation into practice of embryonic stem cell research.
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Keywords: researchers, safely, regenerate, failing, mouse, hearts, programmed, embryonic, stem, cells, researcher, heart, cell
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- Scientists overcome obstacles to stem cell heart repair
12-12-2007 · EurekAlert!
Scientists have overcome two significant obstacles on the road to harnessing stem cells to build patches for damaged hearts. Presenting the research at a UK Stem Cell Initiative conference the researchers will explain how they have made significant progress in maturing beating heart cells derived from embryonic stem cells and in developing the physical scaffolding that would be needed to hold the patch in place in the heart in any future clinical application.
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- Mass. General researchers identify master cardiac stem cell
11-22-2006 · EurekAlert!
Researchers from the Massachusetts General Hospital Cardiovascular Research Center have discovered what appears to be a master cardiac stem cell, capable of differentiating into the three major cell types of the mammalian heart. In a report to appear in the journal Cell, receiving early online release, they describe identifying these progenitor cells in mice, cloning them from embryonic stem cells, and showing that cloned cells can differentiate into cardiac muscle, smooth muscle or endothelial cells.
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- Simple recipe turns human skin cells into embryonic stem cell-like cells
11-20-2007 · EurekAlert!
A simple recipe -- including just four ingredients -- can transform adult human skin cells into cells that resemble embryonic stem cells, researchers report in an immediate early publication of the journal Cell, a publication of Cell Press. The converted cells have many of the physical, growth and genetic features typically found in embryonic stem cells and can differentiate to produce other tissue types, including neurons and heart tissue, according to the researchers.
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- Human derived stem cells can repair rat hearts damaged by heart attack
08-26-2007 · EurekAlert!
When human heart muscle cells derived from embryonic stem cells are implanted into a rat after a heart attack, they can help rebuild the animal's heart muscle and improve function of the organ, scientists report in the September issue of Nature Biotechnology. The researchers also developed a new process that greatly improves how stem cells are turned into heart muscle cells and then survive after being implanted in the damaged rat heart.
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- Researchers discover important tool in understanding differentiation in human embryonic stem cells
10-24-2007 · EurekAlert!
Researchers at the University of Minnesota's Stem Cell Institute have used an existing genetic tool to study how human embryonic stem cells self-renew. The researchers used "knockdown" technology to reduce the expression, and plasmid vectors to increase the expression of oct4, a gene known to be necessary for self renewal. Both procedures resulted in differentiation, but with similar patterns, unlike mouse ES cells that differentiate into a different cell types with oct4 up-and down-regulation.
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- Application of adult stem cells to regenerate hearts having suffered attacks by means of catheter
10-10-2007 · EurekAlert!
A team of cardiologists at the University Hospital of Navarre, in collaboration with the Area of Cell Therapy at the same center, and with the Gregorio Maraсуn Hospital in Madrid, have carried out clinical trials on 50 patients in order to test the efficacy of adult stem sell transplants (in this case, myoblasts), in the heart of persons who have suffered a myocardial attack.
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- UC Davis researchers find evidence of mature heart cell potential in embryonic stem cells
11-27-2007 · EurekAlert!
In a new study, UC Davis researchers report thefirst functional evidence that heart cells derived from human embryonicstem cells exhibit one of the most critical properties of mature adultheart cells, an important biological process called excitation-contractioncoupling.
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- Reprogrammed fibroblasts identical to embryonic stem cells
06-06-2007 · EurekAlert!
Researchers have manipulated mouse fibroblasts and, without using any eggs or embryos, turned them into cells with such developmental elasticity that they appear identical to embryonic stem cells.
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- UF researchers test stem cell therapy for heart patients
10-04-2007 · EurekAlert!
University of Florida doctors treated the first patient in a new study to test whether a person's own stem cells can be used to restore blood flow to the heart by prompting new blood vessels to grow.
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- An ambulance man for muscle damage
12-18-2007 · EurekAlert!
Researchers of the European Molecular Biology Laboratory's Mouse Biology Unit, Italy, and the Harefield Heart Science Centre of Imperial College London, have now discovered a molecular signal that helps muscle regenerate and protects it from atrophy. In this week's issue of the Journal of Cell Biology they report that the naturally occurring protein is a promising candidate for new strategies in treating muscle damage and wasting.
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