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Proteasome activator enhances survival of Huntington's disease neuronal model cells
02-27-2007 · EurekAlert!These remarkable results demonstrate for the first time that it is possible to intervene therapeutically in the proteolytic pathways and organelles that participate in the specific degradation of misfolded and abnormal proteins.
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Keywords: proteasome, activator, enhances, survival, huntington, disease, neuronal, model, cells, enhance, cell
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- Chemical compound found in tree bark stimulates growth, survival of brain cells
10-01-2007 · EurekAlert!
Researchers have identified a compound in tree bark that mimics the chemical reactions of a naturally occurring molecule in the brain responsible for stimulating neuronal cell signaling. The tree bark compound, known as gambogic amide, behaves much like Nerve Growth Factor, a molecule found in the brain. NGF binds to TrkA, a neuronal receptor, and activates neuronal signaling. It is known that the loss of TrkA density correlates with neuronal atrophy and severe cognitive impairment such as that associated with Alzheimer's disease.
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- Pathway to cell death redefined in landmark study
09-20-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine have determined that an intracellular protein called serpin-6 is crucial to the repair and survival of cell injury. Controlling the process could pave the way to new treatments for cancer, stroke, heart disease, neurological disorders and other killer illnesses. Using a primitive animal model, the scientists also have made cascade of cell death and the role of serpin-6 in saving cells dramatically -- and explosively -- visible.
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- Reprogrammed human adult stem cells rescue diseased muscle in mice
12-12-2007 · EurekAlert!
Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease. The research, published by Cell Press in the December issue of Cell Stem Cell, represents a significant advance toward the future development of a gene therapy that uses a patient's own cells to treat this devastating muscle-wasting disease.
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- Cardiac stem cell therapy closer to reality
12-27-2007 · EurekAlert!
The current issue of Cell Transplantation is devoted to the "Proceedings of the Third Annual Conference on Cell Therapy for Cardiovascular Disease." Cardiac stem cell therapy involves delivering a variety of cells into hearts following myocardial infarction or chronic cardiomyopathy. An overview of current research and research goals is presented, followed by the results of studies aimed at improving implanted cell survival and the repair process, as well as several techniques aimed at improving efficacy.
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- Method to prevent hemorrhagic complications of thrombolytic therapy of blood clots is discovered
07-02-2007 · EurekAlert!
The now reported study led by Dr. Perttu J. Lindsberg from the Helsinki University Central Hospital investigated thrombolytics-related brain hemorrhage formation in an experimental stroke model in rats. It found that, in addition to the clot lysing effect, the drug used for this purpose, alteplase (recombinant tissue plasminogen activator) also possesses proinflammatory properties and activates and degranulates mast cells, a kind of tissue-based immune cell.
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- Nanomedicine opens the way for nerve cell regeneration
05-20-2007 · EurekAlert!
The ability to regenerate nerve cells in the body could reduce the effects of trauma and disease in a dramatic way. In two presentations at the NSTI Nanotech 2007 Conference, researchers describe the use of nanotechnology to enhance the regeneration of nerve cells.
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- Stem cells show promise for treating Huntington's disease
09-25-2007 · EurekAlert!
Paying close attention to how a canary learns a new song has helped scientists open a new avenue of research against Huntington's disease -- a fatal disorder for which there is currently no cure or even a treatment to slow the disease. Scientists used gene therapy to guide the development of endogenous stem cells in the brains of mice affected by a form of Huntington’s, generating new medium spiny neurons -- the cell lost in Huntington's disease.
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- Researchers find 'zip code' spurs cargo transport in neurons
10-24-2006 · EurekAlert!
Getting molecular cargo from the cell body to the synapse of nerve cells is crucial for learning and memory, even for survival of the cell itself. New research conducted at Brown University and the Marine Biological Laboratory in Woods Hole, Mass., shows that a single peptide can load and direct this biological material. This peptide "ZIP Code" comes from amyloid precursor protein, the principal player in the development of Alzheimer's disease.
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- Drug protects brain cells in Huntington's disease model, researchers find
07-24-2007 · UT Southwestern Medical Center
A drug used in some countries to treat the symptoms of Huntington's disease prevents death of brain cells in mice genetically engineered to mimic the hereditary condition, UT Southwestern Medical Center researchers have found.
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- Scientists identify a mouse embryonic stem cell more like our own
06-27-2007 · EurekAlert!
Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem cells, the National Institutes of Health announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
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