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MicroRNA found to regulate gene involved in cancer
03-02-2007 · Massachusetts Institute of Technology (MIT)A microRNA directly regulates a gene implicated in human cancers, researchers from the Whitehead Institute and MIT reported in the Feb. 22 online issue of Science.
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Keywords: microrna, regulate, gene, involved, cancer
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- MicroRNA helps prevent tumors
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Researchers have found that when a single mircoRNA molecule is unable to regulate a specific cancer-related gene, tumors result.
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- Researchers identify key gene that may be a marker of breast cancer metastasis
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Researchers at Fox Chase Cancer Center have identified an important gene involved in the spread of breast cancer that has developed resistance to long-term estrogen deprivation. The gene may prove to be a useful marker for predicting which patients have the greatest risk of breast cancer recurrence so their doctors can offer the most appropriate treatment plan.
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- Unique role for blood formation gene identified
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All blood cell production in adults depends on the steady work of a vital gene that if lost results in early bone marrow failure, Dartmouth Medical School cancer geneticists have found. Their research reveals an unexpected role for the gene in sustaining the adult blood-forming system, and opens novel strategies for targeting the gene, which is often involved in a type of childhood leukemia.
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- 'Network' approach identifies potential breast cancer susceptibility gene
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- Jefferson scientists find aging gene also protects against prostate cancer development
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Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth. Yet they also know that anti-estrogen therapies don't work to treat breast or ovarian cancer that might develop. That paradox has led scientists to question exactly how, or if, estrogen is involved in cancer development and whether removal of ovaries makes sense.
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- Molecules may help predict survival in liver cancer
01-30-2008 · EurekAlert!
Tiny molecules that help cells regulate which proteins they make might one day help doctors predict which liver-cancer patients are likely to live longer than others. Researchers compared levels of microRNA in tumor cells and adjacent nontumor cells from liver-cancer patients, most of whom also had hepatitis and cirrhosis. Patients with poor disease-free survival had low overall levels of 19 particular microRNAs compared with those showing better survival after 16 years of follow-up.
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