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Therapeutic peptide frees the protein p73 to kill tumor cells
03-08-2007 · EurekAlert!p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50 percent of human cancers. Now, a new study indicates that targeting the p53-related protein p73 in mice induces the regression of established tumors of human origin, leading to the suggestion that p73 might be a viable target for developing anticancer therapeutics.
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Keywords: therapeutic, peptide, frees, protein, p73, kill, tumor, cells, free, cell
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This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, March 8, 2006, in the JCI, including: Therapeutic peptide frees the protein p73 to kill tumor cells; CDX2: a protein that promotes leukemia; Mesenchymal stem cells are long-term tissue residents; SPDEF makes the lungs more “asthma-like”; and SHIP1 in platelets practices first aid.
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