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Living Long on Less? Mouse and human cells respond to slim diets

03-10-2007 · Science News Online

Some animals live longer on reduced-calorie diets, and in a recent experiment people on such diets had many of the cellular changes that those long-lived animals did.

Keywords: living, mouse, human, cells, respond, slim, diets, cell, diet

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JCI table of contents: June 21, 2007
06-21-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, June 21, 2007 including: A diet rich in omega-3 fatty acids may lower prostate cancer genetic risk; Mending a broken heart: How to boost the number and function of cardiac stem cells; Autophagy plays a role in heart's poor response to stress; New mouse model for the study of some forms of human hypertension; and others.
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Soft-cell approach cuts animal tests
02-06-2007 · EurekAlert!
A new way to test the safety of the air we breathe is proving faster, cheaper and more humane than exposing laboratory animals to airborne chemical hazards, say UNSW scientists. Researchers at the university's Chemical Safety and Applied Toxicology Laboratories have developed an animal-free alternative that exposes living human cells to air pollutants inside a small chamber. The breakthrough could fast-track scientific understanding of the threat to human health posed by thousands of airborne chemical compounds.
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Team of scientists develops non-invasive method to track nerve-cell development in live human brain
11-08-2007 · EurekAlert!
A team of scientists including researchers at Cold Spring Harbor Laboratory have identified and validated the first biomarker that permits neural stem and progenitor cells to be tracked, non-invasively, in the brains of living human subjects. This important advance could lead to significantly better diagnosis and monitoring of brain tumors and a range of serious neurological and psychiatric disorders.
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LCT reports major step forward for islet transplantation in diabetes patient
03-29-2007 · EurekAlert!
Living Cell Technologies has published evidence outlining the survival and identification of live porcine islet cells and insulin production in a human patient with diabetes 10 years after he received a micro-encapuslated pig islet cell transplant. The paper outlines how LCT has demonstrated the long-term safety, viability and function of its encapsulated porcine islets in a human patient over an extended period of time, without the use of immunosuppression.
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Scientists identify a mouse embryonic stem cell more like our own
06-27-2007 · EurekAlert!
Scientists have discovered a new type of mouse embryonic stem cell that is the closest counterpart yet to human embryonic stem cells, the National Institutes of Health announced today. The cells are expected to serve as an improved model for human ES cells in studies of regeneration, disease pathology and basic stem cell biology.
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Researchers discover important tool in understanding differentiation in human embryonic stem cells
10-24-2007 · EurekAlert!
Researchers at the University of Minnesota's Stem Cell Institute have used an existing genetic tool to study how human embryonic stem cells self-renew. The researchers used "knockdown" technology to reduce the expression, and plasmid vectors to increase the expression of oct4, a gene known to be necessary for self renewal. Both procedures resulted in differentiation, but with similar patterns, unlike mouse ES cells that differentiate into a different cell types with oct4 up-and down-regulation.
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Antibody retards growth and induces death in liver cancer cells
07-11-2007 · EurekAlert!
Researchers from the University of Pittsburgh School of Medicine report a significant new advance in the search for an effective treatment for human liver cancer. Using a newly available monoclonal antibody, they demonstrated dramatic reductions in tumor cell proliferation and survival in human and mouse hepatocellular cancer cell lines. This finding has significant implications not only for the treatment of liver cancer but for a number of different types of cancer.
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Thumb-size microsystem enables cell culture and incubation
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Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease. The research, published by Cell Press in the December issue of Cell Stem Cell, represents a significant advance toward the future development of a gene therapy that uses a patient's own cells to treat this devastating muscle-wasting disease.
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