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Genetic pathways to curable and incurable forms of pancreatic cancer identified
03-12-2007 · EurekAlert!The genetic sequence has been discovered that leads to a rare form of pancreatic ductal adenocarinoma.
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Keywords: genetic, pathways, curable, incurable, forms, pancreatic, cancer, identified, pathway, form
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- First familial pancreatic cancer gene identified
12-11-2006 · EurekAlert!
At least 10 percent of pancreatic cancers are thought to be familial, i.e., caused by inherited genetic mutations. The responsible genes have so far remained elusive, but one of the research teams that had been on a pancreatic cancer gene hunt for years now reports success: Teri Brentnall (University of Washington), David Whitcomb (University of Pittsburgh), and colleagues publish the identification of the palladin gene as the one mutated in a large family they had been studying for a while.
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- Jefferson pharmacologist says biomarker discovery bodes well for better cancer diagnostics
05-01-2007 · EurekAlert!
A pharmacologist at the Kimmel Cancer Center at Jefferson says that new findings suggesting a genetic marker can help distinguish between chronic pancreatitis and pancreatic cancer and gauge who will do well with cancer treatment have important implications for improved cancer diagnostics and tumor profiling. In an editorial he co-authored May 2 in JAMA, Scott Waldman, M.D., Ph.D., says that researchers at Ohio State University have identified "a new level of biological regulation."
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- Gene mutations linked to hereditary lung disease
03-28-2007 · EurekAlert!
Scientists at Johns Hopkins have identified the genetic culprits that trigger a hereditary form of a fatal lung disease. The findings, published in the March 29, 2007, issue of the New England Journal of Medicine, may provide new directions in diagnosis and treatment for families that inherit genes for the disease, as well as for those that develop non-inherited forms of the illness.
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- UF scientists identify cancer virus' genetic targets
05-10-2007 · EurekAlert!
University of Florida researchers have identified specific human genes targeted by a virus believed to cause Kaposi's sarcoma, a rare form of cancer associated with AIDS and with organ transplants that causes patches of red or purple tissue to grow under people's skin.
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- Genetic marker linked to aggressive prostate cancer
05-20-2007 · EurekAlert!
Northwestern University researchers have discovered that a recently identified genetic marker for prostate cancer is linked to a highly aggressive form of the disease. These findings ultimately will aid the development of a simple blood test to predict who is susceptible to this aggressive cancer. Knowing which patients carry this genetic marker also will guide doctors in how they treat the cancer. The study showed a strong hereditary component to this aggressive cancer.
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- Mayo Clinic Cancer Center -- individualizing treatment for multiple myeloma patients
12-10-2006 · EurekAlert!
Researchers at Mayo Clinic Cancer Center, in cooperation with industry partners, have, for the first time, identified tumor specific alterations in the cellular pathway by which the multiple myeloma drug bortezomib (Velcade) works, and they have identified nine new genetic mutations in cancer cells that should increase a patient's chance of responding to the agent.
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- Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
08-13-2007 · EurekAlert!
Two new studies may lead to the development of more effective therapies for individuals with multiple myeloma, a common and incurable blood cell cancer. The research, published by Cell Press in the August issue of the journal Cancer Cell, provides new insight into the molecular mechanisms that underlie aberrant NF-κB activity in MM tumor cells and underscores the relevance of the signaling pathway as a target for MM therapy.
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- Kidney cancer drug attacks a major type of acute myeloid leukemia
01-29-2008 · EurekAlert!
A drug used to treat kidney cancer also targets a genetic mutation active in about one third of patients with acute myeloid leukemia, the most common and lethal form of adult leukemia, researchers at The University of Texas M. D. Anderson Cancer Center report in the Jan. 29 edition of the Journal of the National Cancer Institute.
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- Tracing the pathways of neurofibromatosis
01-18-2007 · EurekAlert!
New research into the mechanisms of neurofibromatosis finds that flaws in the gene Nf1 can lead to a biochemical domino effect that results in tumors. The research, which appears in the January 10 issue of the Journal of Neuroscience, seeks to identify the biochemical pathway responsible for tumors in people with the genetic disorder. Researchers built their case based on evidence from dozens of painstaking experiments on genetically engineered fruit flies.
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- Scientists find new genes for Crohn's disease
04-15-2007 · EurekAlert!
A consortium of US and Canadian researchers is reporting in today's online issue of Nature Genetics that they have discovered several more genetic variations that are strongly linked to an increased risk for the disease. The discovery of these Crohn's disease-associated genetic variants has identified several key biological pathways that will be the focus of further research to understand how the debilitating inflammatory process is initiated and maintained in many cases of the disease.
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