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Therapeutic unshackles p53 and causes tumor regression

Infection with Kaposi's sarcoma virus (KSHV) can cause 3 types of tumor, including primary effusion lymphoma (PEL). Although KSHV has been known to cause tumors for many years, there are no effective therapies for KSHV-induced tumors. In a new study it is shown that the small-molecule inhibitor Nutlin-3a has antitumor effects in a mouse xenograft model of PEL, indicating that it might provide a viable therapeutic option for the treatment of individuals with PEL.

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Keywords: therapeutic, unshackles, p53, causes, tumor, regression, unshackle, cause

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1. JCI table of contents: March 15, 2007
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   This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, March 15, 2007, in the JCI, including: "Gallium: a new antibacterial agent?"; "Therapeutic unshackles p53 and causes tumor regression"; "Taking away Cbl-b improves antitumor immune responses"; "MCP3 entices monocytes to leave the bone marrow"; and "Artificial lymph nodes as good as real ones."
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