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Brain Fix: Stem cells supply missing enzyme
03-17-2007 · Science News OnlineBrain stem cells implanted into sick mice restored a missing enzyme and extended life span by 70 percent.
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Keywords: brain, fix, stem, cells, supply, missing, enzyme, cell
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- Sentry enzyme blocks two paths to Parkinson's disease
02-01-2007 · EurekAlert!
The degeneration of brain cells that occurs in Parkinson's disease may be caused by either externally provoked cell death or internally initiated suicide when the molecule that normally prevents these fatal alternatives is missing, according to studies in mouse models by investigators at St. Jude Children's Research Hospital.
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- MIT creates 3-D scaffold for growing stem cells
12-26-2006 · EurekAlert!
Stem cells grew, multiplied and differentiated into brain cells on a new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system.
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- Neural stem cell study reveals mechanism that may play role in cancer
09-04-2007 · EurekAlert!
In the dynamic world of the developing brain, neural stem cells give rise to neurons deep within the brain’s fluid-filled ventricles. These newborn neurons then migrate along the stem cell fibers up to the neocortex, the seat of higher cognitive functions. Now, scientists have discovered a key mechanism of this migration -- one that may also play an important role in other developmental processes and diseases, including cancer.
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- Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
01-17-2008 · EurekAlert!
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.
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- MIT creates 3D scaffold for growing stem cells
12-27-2006 · Massachusetts Institute of Technology (MIT)
An MIT engineer and colleagues report that stem cells grew, multiplied and differentiated into brain cells on their new three-dimensional scaffold of tiny protein fragments designed to be more like a living body than any other cell culture system.
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- UCSF stem cell study reveals cells' capability in mouse brain tissue repair
12-14-2006 · EurekAlert!
UCSF scientists have determined that adult stem cells in a specific region of the mouse brain have a built-in mechanism that allows the cells to participate in the repair and remodeling of damaged tissue in the region.
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- Neural stem cells lend the brain a surprising capacity for self-repair
12-14-2006 · EurekAlert!
The brain contains stem cells with a surprising capacity for repair, researchers report in the Dec. 15 issue of the journal Cell, published by Cell Press. The novel insight into the brain's natural ability to heal might ultimately have clinical implications for the treatment of brain damage, according to the researchers.
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- Some antipsychotic drugs may be missing their mark
12-31-2007 · EurekAlert!
Drugs that treat depression and schizophrenia might not be triggering the most appropriate response in brain cells, new research suggests. This study examined the early chemical events that happen when a particular serotonin receptor on brain cells is stimulated by serotonin and by a hallucinogenic agent thought to mimic serotonin. The findings show that although both compounds activate this receptor, they trigger different chemical pathways inside the cell.
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- Experimental anti-cancer drug made from corn lillies kills brain tumor stem cells
08-30-2007 · EurekAlert!
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
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- Stroke victims may benefit from stem cell transplants
01-28-2008 · EurekAlert!
Two studies published in the current issue of Cell Transplantation examine the potential for cell transplants to benefit stroke victims. When injected into animal models and tracked via chemical tags and imaging, mensenchymal stem cells in one study, and bone marrow stromal cells in a second study, migrated within one to two weeks to affected brain areas and became therapeutically active. Both studies suggest that novel stem cell therapies can be developed.
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