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MIT technique reveals inner lives of red blood cells
10-16-2006 · Massachusetts Institute of Technology (MIT)For the first time, researchers at MIT can see every vibration of a cell membrane, using a technique that could one day allow scientists to create three-dimensional images of the inner workings of living cells.
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Keywords: mit, technique, reveals, inner, lives, red, blood, cells, reveal, live, cell
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- How red blood cells nuke their nuclei
02-10-2008 · EurekAlert!
Late in their development, mammalian red blood cells lose their nuclei when a ring of actin filaments contracts and pinches off a segment of the cell that mainly contains the nucleus. Relevance: This is the first study to reveal the proteins involved as a red blood cell loses its nucleus. The researchers plan to further investigate the entire process of red blood cell formation, which may lead to insights about genetic alterations that underlie certain red blood cell disorders.
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- There goes the neighborhood: Vascular niche nurtures brain tumor stem cells
01-16-2007 · EurekAlert!
New research published in the January 2007 issue of the journal Cancer Cell, published by Cell Press, reveals that small blood vessels associated with brain tumors orchestrate a distinct microenvironment that is critical for maintaining cancer stem cells (CSCs). Importantly, antiangiogenic drugs that disrupt this microenvironment reduce the CSC population and arrest tumor growth.
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- MIT-led team ID's malaria-inducing protein
05-21-2007 · Massachusetts Institute of Technology (MIT)
An international team of researchers led by an MIT professor has demonstrated how a key protein in the malaria-inducing parasite Plasmodium falciparum infects red blood cells, causing them to lose their ability to flow through tiny blood vessels.
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- Anticancer drugs might be of benefit to sickle-cell patients
12-06-2007 · EurekAlert!
Although some individuals with the inherited blood disorder sickle cell disease benefit from treatment with hydroxyurea, which increases fetal hemoglobin expression, it does not work for all sickle-cell patients. Now, hope for a new therapy has been provided by the observation that the anticancer drugs lenalidomide and pomalidomide were more effective than hydroxyurea at inducing HbF expression by red blood cells derived in vitro from CD34+ cells from both healthy and sickle-cell individuals.
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- Pre-cancerous blood diseases can be products of their environment
06-14-2007 · EurekAlert!
When blood-forming stem cells misbehave, causing pre-cancerous conditions that can sometimes even progress to leukemia, the problem might not always lie with them. Rather, two studies in the June 15 issue of the journal Cell, published by Cell Press, reveal that a bad environment might be to blame.
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- Study reveals how stem cells decide to become either skeletal or smooth muscle
10-10-2007 · EurekAlert!
Researchers have discovered that a key protein controls how stem cells 'choose' to become either skeletal muscle cells that move limbs, or smooth muscle cells that support blood vessels. The results suggest new ways to treat atherosclerosis and cancer, diseases that involve the creation of new blood vessels from stem cell reserves that would otherwise replace worn out skeletal muscle.
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- New MIT technique weighs single living cells
04-25-2007 · Massachusetts Institute of Technology (MIT)
For the first time, MIT researchers have found a way to measure the mass of single cells with high accuracy. The technique could allow researchers to develop inexpensive diagnostic devices and offer a unique glimpse into cell division.
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- New cell culturing method pumps up the volume
09-24-2007 · EurekAlert!
In a breakthrough that will likely accelerate research aimed at cures for hearing loss, tinnitus and balance problems, scientists have perfected a laboratory culturing technique that provides a reliable new source of cells critical to understanding certain inner-ear disorders.
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- Brown scientists map structure of DNA-doctoring protein complex
12-06-2006 · EurekAlert!
Mobile DNA, which inserts foreign genes into target cells, is a powerful force in the march of evolution and the spread of disease. Working with the lambda virus and E. coli bacteria, Brown University biologists have solved the structure of a six-protein complex critical to performing this gene-grafting surgery. The technique they developed could be used to reveal the structure of other critical protein complexes, landing the work on the cover of Molecular Cell.
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- Soliris (eculizumab) data to be presented at American Society of Hematology
12-08-2006 · EurekAlert!
Data on Soliris™ (eculizumab) for patients with paroxysmal nocturnal hemoglobinuria (PNH) will be presented at the ASH Annual Meeting in Orlando, Florida, Dec. 9th to 12th by leading investigators in the Soliris™ clinical studies. PNH, a rare and life-threatening form of hemolytic anemia, is an acquired genetic blood disorder characterized by destruction of red blood cells by the body’s complement system. Patients with PNH lack naturally-occurring complement inhibitors which normally prevent red blood cell destruction.
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