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Notorious cancer gene may work by destroying messenger

A new study suggests how a notorious cancer gene may contribute to tumor growth. The insight emerged from a long-running study of a protein called PMR1, the key player in an unusual mechanism that cells use to quickly stop production of certain important proteins.

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1. Gene variations point to why lung cancer drugs work better in Japanese vs. US patients
   06-02-2007 · EurekAlert!
   Recent clinical trials revealed that Japanese lung cancer patients survived longer and had a higher rate of side effects than US patients taking the same two drugs, paclitaxel and carboplatin. Now a new study by the Southwest Oncology Group uncovers genetic differences that may explain why. The results, embargoed for release 8:30 a.m. ET Saturday, June 2, are being highlighted at the American Society of Clinical Oncology annual meeting.
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2. It is important to demonstrate the influence of the microenvironment in the process of metastasis
   12-20-2007 · EurekAlert!
   In the work defended at the University of the Basque Country, an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients.
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3. Unique role for blood formation gene identified
   09-12-2007 · EurekAlert!
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4. New clues to breast cancer development in high-risk women
   09-11-2007 · EurekAlert!
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5. Annals of Internal Medicine tip sheet for Oct. 2
   10-01-2007 · EurekAlert!
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6. Jefferson scientists find protein may be key in developing deadly form of pancreatic cancer
   10-11-2007 · EurekAlert!
   A tumor-blocking protein previously implicated in prostate and breast cancer development may also be behind the most aggressive type of pancreatic cancer. Researchers have discovered that the protein pp32 -- which normally applies the brakes on a cancer-causing gene -- is missing in an aggressive form of pancreatic cancer. Though the work is preliminary, the scientists say, the absent protein could eventually become a marker for the disease and a potential drug target.
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7. Enzyme structure reveals new drug targets for cancer and other diseases
   02-14-2008 · EurekAlert!
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8. Brown cancer biologists identify major player in cell growth
   02-06-2007 · EurekAlert!
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9. If you think cancer genes are simple, you don't know JAK
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10. Jefferson scientists find tumor suppressor gene protects against pre-cancerous development
    11-01-2006 · EurekAlert!
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