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UCLA scientists design masks to hide genetic mutations from cell
03-19-2007 · EurekAlert!UCLA scientists have devised a novel way to correct abnormal gene splicing - a common mutation that often leads to disease. A custom mask prevents the cell from seeing the genetic defect and restores the splicing to the correct location in the gene.
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Keywords: ucla, scientists, design, masks, hide, genetic, mutations, cell, scientist, mask, mutation
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- UCLA scientists working to create smaller, faster integrated circuits
12-19-2007 · EurekAlert!
Integrated circuits are the "brain" in computers, cell phones, and many other electronic devices. A team of UCLA scientists has demonstrated substantial improvements in integrated circuits, also known as silicon chips, achieved not by costly improvements in manufacturing, but by improved computer-aided design software based on better mathematical algorithms.
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- Scientists find major susceptibility gene for Crohn's disease
10-26-2006 · EurekAlert!
Researchers report the discovery of a new genetic link to Crohn's disease. Mutations of a gene, which codes for a receptor in a major inflammatory pathway, are strongly associated with Crohn's, they found. Surprisingly, one type of mutation appears to confer significant protection, prioritizing a crucial target for drugs that might better manage Crohn's disease and ulcerative colitis. More than 1 million Americans have Crohn's or colitis, known collectively as inflammatory bowel disease.
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- Human embryonic stem cells derived from preimplantation genetically diagnosed embryos
11-14-2007 · EurekAlert!
A human stem cell line derived from embryos that were identified by preimplantation genetic diagnosis to carry the mutation for fragile X syndrome has provided an unprecedented view of early events associated with this disease. In addition to giving scientists fresh insight into fragile X, results from this unique model system have emphasized the value of this new source of embryonic stem cells and may have a significant impact on the way that genetic diseases are studied in the future.
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- Study led by Scripps Research scientist reveals little-known cell networks vital to circadian rhythm
05-03-2007 · EurekAlert!
In a wide-ranging systems biology study of circadian rhythm, a multi-institutional collaboration led by Scripps Research Institute Professor Steve Kay has uncovered some little-known cellular mechanisms for sustaining circadian rhythm and limiting the impact of genetic clock mutations in mammals. The new findings could have important implications for future circadian studies, and point researchers toward new ways to manipulate human circadian rhythm at the molecular level to treat diseases such as bipolar disorder.
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- Study uncovers mutation responsible for Noonan Syndrome
12-04-2006 · EurekAlert!
Scientists have discovered that mutations in a gene known as SOS1 account for many cases of Noonan syndrome (NS), a common childhood genetic disorder which occurs in one in 1,000-2,500 live births. NS is characterized by short stature, facial abnormalities and learning disabilities, as well as heart problems and predisposition to leukemia.
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- Study reveals how some molecules inhibit growth of lung cancer cells
03-12-2007 · EurekAlert!
By mapping the interlocking structures of small molecules and mutated protein "receptors" in non-small cell lung cancer (NSCLC) cells, scientists at Dana-Farber Cancer Institute and their colleagues have energized efforts to design molecules that mesh with these receptors, potentially interfering with cancer cell growth and survival.
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- Cellulose nanocrystal research could lead to new vaccines, computer inks
03-26-2007 · EurekAlert!
A wood scientist is attaching antibodies to the surface of cellulose crystals. This design enables the nanocrystals to block cell receptors in the body. The process may eventually be used to create vaccines. Through the same receptor-blocking method, this process can combat the effects of some diseases involving inflammation of blood vessels, including diabetes, rheumatoid arthritis and certain cancers.
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- Scientists find mutations that let bird flu adapt to humans
11-15-2006 · EurekAlert!
By comparing influenza viruses found in birds with those of the avian virus that have also infected human hosts, researchers have identified key genetic changes required for pandemic strains of bird flu.
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- Scientists uncover new target in cancer mutation puzzle
02-18-2007 · EurekAlert!
University of Rochester scientists, while investigating the two most frequent types of mutations in cancer, discovered a possible new route to treatment that would take advantage of the mutations instead of trying to repair them. The research is reported online this week in the journal Nature Structural & Molecular Biology.
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- Bigelow Laboratory Scientists develop new approach to study marine microbes
05-21-2007 · EurekAlert!
In a paper published this month in the Proceedings of the National Academy of Sciences, Dr. Ramunas Stepanauskas and Dr. Michael Sieracki have proven a new method of identifying genetic codes of ocean microbes from a single cell.
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