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Protein structures for the entire yeast proteome
03-19-2007 · EurekAlert!Protein three-dimensional structures were predicted for all Saccharomyces cerevisiae domains that were found to have no sequence similarity to any proteins of known structure.
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Keywords: protein, structures, entire, yeast, proteome, structure
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- Crystal structure enables tailoring of pharmaceuticals against asthma
07-16-2007 · EurekAlert!
Researchers at Karolinska Institutet in Sweden have managed to elucidate the crystal structure of a human membrane protein -- LTC4 synthase -- which has a major influence on the development of asthma. LTC4 synthase is extremely difficult to analyze, and previously only low resolution information has been available on two membrane protein structures from human. The scientists now believe that their work will enable the development of new and better therapeutics against inflammations in the pulmonary tract.
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- First high-res 3D structures of mammalian HSP90 protein solved
10-12-2007 · EurekAlert!
Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in Molecular Cell. Gewirth's study confirms his hypothesis that this protein -- GRP94 -- is from the same family as the better known HSP90 proteins.
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- Self-assembling nano-ice discovered at UNL -- Structure resembles DNA
12-11-2006 · EurekAlert!
UNL chemist Xiao Cheng Zeng and his team discovered double helixes of ice molecules that resemble the structure of DNA and self-assemble under high pressure inside carbon nanotubes. This discovery could have major implications for scientists in other fields who study the protein structures that cause diseases such as Alzheimer's and bovine spongiform ecephalitis. It could also help guide those searching for ways to target or direct self-assembly in nanomaterials.
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- Unique partnership produces life-critical 3D structures
03-28-2007 · EurekAlert!
Most diseases are caused by malfunctions in the body’s complex protein machinery. The next generation of drugs will be designed on the basis of 3D protein models that scientists are creating. The Structural Genomics Consortium laboratory at Karolinska Institutet in Sweden has now made available the structure of PARP3, the four hundredth structure in this unique project to chart the body’s proteins.
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- Scientists reveal structure of gateways to gene control
03-28-2007 · EurekAlert!
The first complete high-resolution map of structures that control how genes are packaged and regulated throughout an entire genome has been compiled by Penn State scientists. The research suggests how certain nucleosomes control whether a gene's function can be turned on. The study reveals an intimate relationship between the architecture of nucleosomes and the underlying DNA sequences they regulate, including a critical gateway that must be unlocked before a gene can be transcribed.
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- New gene prediction method capitalizes on multiple genomes
12-19-2007 · EurekAlert!
A new approach to computationally predicting the locations and structures of protein-coding genes in a genome has been published in the online open access journal, Genome Biology.
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- Short bacterial protein is surprisingly versatile
01-17-2008 · Massachusetts Institute of Technology (MIT)
MIT researchers have discovered that the reason an unusually short bacterial protein has many more interactions than would normally be expected of something its size is probably due to its lack of formal structure.
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- Scientists retrace evolution with first atomic structure of an ancient protein
08-16-2007 · EurekAlert!
Scientists have determined for the first time the atomic structure of an ancient protein, revealing in unprecedented detail how genes evolved their functions.
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- DNA ends: Common tool, different job
02-13-2007 · EurekAlert!
Every time a cell repairs or replicates its DNA, the resulting single strand is wrapped up by a dedicated protein complex. In eukaryotes or organisms whose cells have a nucleus, this job is handled by a tripartite complex called replication protein A (RPA). Researchers at the Salk Institute for Biological Studies have now unearthed a novel RPA-like complex that specifically homes in on the short single-stranded DNA "tail" end of yeast chromosomes.
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- Discovery may pave the way for a new class of diabetes drugs
08-29-2007 · EurekAlert!
A multidisciplinary team led by researchers at the University of California, San Diego has determined the structure of a protein found in cells that shows potential as a target for the development of new drugs to treat diabetes.
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