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Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
03-21-2007 · EurekAlert!Scientists have found a gene mutation that can dramatically reduce the number of colon polyps that develop, potentially cutting the risk of cancer. Researchers studying mice prone to develop polyps discovered that animals carrying the damaged gene had about 90 percent fewer polyps in the small intestine and colon. Because people with large numbers of polyps are at higher risk for colon cancer, the finding may provide new ways to diagnose, prevent and treat it.
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- Scientists identify a gene that may suppress colorectal cancer
03-21-2007 · EurekAlert!
In Genome Research, a husband-and-wife research team from Thomas Jefferson University report the discovery of a gene that, when mutated, may suppress colorectal cancer. To conduct the study, the researchers used a strain of mice that develop polyps, or small growths of tissue, in the digestive tract -- the harbingers of cancer. When these mice possessed one copy of the mutated gene, the incidence of small intestinal and colon polyps were reduced by about 90 percent.
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- Jefferson scientists find aging gene also protects against prostate cancer development
11-27-2006 · EurekAlert!
Cancer researchers have found that a gene that is involved in regulating aging also blocks prostate cancer cell growth. They have shown that the enzyme SIRT1 can block the growth of treatment-resistant prostate cancer cells that overexpress a mutation for the androgen receptor. The scientists hope the newly found connection will aid in better understanding the development of prostate cancer and lead to new drugs against the disease.
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- Jefferson scientists uncover role of cancer stem cell marker: controlling gene expression
01-17-2008 · EurekAlert!
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary advance in the understanding of the function of a gene previously shown to be part of an 11-gene "signature" that can predict which tumors will be aggressive and likely to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling large scale changes in gene expression, one of the hallmarks of cancer cells.
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- Scientists solve structure of gene regulator that plays key role in cancer
02-13-2008 · EurekAlert!
Scientists at the Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans. Their research paves the way for the development of new cancer therapies. The scientists have elucidated the 3-D structure of a key segment of p300/CBP, one of the most studied enzymes in the HAT family. Aberrant p300/CBP activity contributes to pancreatic, colon, and lung cancer and also can suppress tumors.
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- Jefferson scientists see breast cancer gene activity from outside the body
11-28-2007 · EurekAlert!
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body. This technology might someday help physicians to detect and classify cancer, enabling them to find cancerous breast tumors as early as possible, and determine the appropriate treatment.
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- Scientists map key landmarks in human genome
01-16-2007 · EurekAlert!
Dana-Farber Cancer Institute researchers have developed a powerful method for charting the positions of key gene-regulating molecules called nucleosomes throughout the human genome. The mapping tool could help uncover important clues for understanding and diagnosing cancer and other diseases, the scientists say. Moreover, it may shed light on the role of nucleosomes in the process of "reprogramming" an adult cell to its original embryonic state, which is a critical operation in cloning.
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- Common cancer gene sends death order to tiny killer
05-31-2007 · EurekAlert!
Scientists at Johns Hopkins have discovered one way the p53 gene does what it's known for -- stopping the colon cancer cells. Their report will be published in the June 8 issue of Molecular Cell.
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- Jefferson scientists show gene reverts cancer genes to normal, predicts breast cancer prognosis
10-31-2006 · EurekAlert!
Scientists have shown that the activity of a gene that commandeers other cancer-causing genes, returning them to normal, can predict the prognosis of an individual with breast cancer. They looked at cancer cells from more than 2,000 breast cancer patients and found that this commandeering or "organizing" ability is increasingly lost in cancer cells and associated with the progression of disease. The more the gene is expressed in breast cancer, the better the patient did.
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- Colon cancer a disease of hormone deficiency, Jefferson team finds
08-01-2007 · EurekAlert!
Researchers have found new evidence suggesting that colon cancer is a disease of missing hormones that could potentially be treated by hormone replacement therapy.Early in colon cancer development, two intestinal cell growth-controlling hormones are "lost," disrupting the activity of the hormones' receptor, GCC. Using two mouse models of colon cancer development in people, the scientists showed that GCC signaling blocks tumors from forming, meaning that colon cancer could be a disease of hormone insufficiency.
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- Scientists uncover new target in cancer mutation puzzle
02-18-2007 · EurekAlert!
University of Rochester scientists, while investigating the two most frequent types of mutations in cancer, discovered a possible new route to treatment that would take advantage of the mutations instead of trying to repair them. The research is reported online this week in the journal Nature Structural & Molecular Biology.
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