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Scientists identify a gene that may suppress colorectal cancer
03-21-2007 · EurekAlert!In Genome Research, a husband-and-wife research team from Thomas Jefferson University report the discovery of a gene that, when mutated, may suppress colorectal cancer. To conduct the study, the researchers used a strain of mice that develop polyps, or small growths of tissue, in the digestive tract -- the harbingers of cancer. When these mice possessed one copy of the mutated gene, the incidence of small intestinal and colon polyps were reduced by about 90 percent.
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Keywords: scientists, identify, gene, suppress, colorectal, cancer, scientist
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- Jefferson scientists uncover gene mutation that cuts colon polyps, may suppress cancer
03-21-2007 · EurekAlert!
Scientists have found a gene mutation that can dramatically reduce the number of colon polyps that develop, potentially cutting the risk of cancer. Researchers studying mice prone to develop polyps discovered that animals carrying the damaged gene had about 90 percent fewer polyps in the small intestine and colon. Because people with large numbers of polyps are at higher risk for colon cancer, the finding may provide new ways to diagnose, prevent and treat it.
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- CSHL scientists identify and repress breast cancer stem cells in mouse tissue
12-17-2007 · EurekAlert!
By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue -- cells that are widely thought to give rise to cancer.
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- A gene for metastasis
08-28-2007 · EurekAlert!
Weizmann Institute Scientists reveal the actions of a key player in colorectal cancer.
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- Scientists find new agent to fight genetic disorders -- Zorro-Locked Nucleic Acid
04-30-2007 · EurekAlert!
A new agent, "Zorro-LNA," may stop some genetic disorders in their tracks. An article appearing in The FASEB Journal's June 2007 issue describes how researchers developed Zorro-LNA to bind with both strands of a gene's DNA, effectively disabling it. This has clinical implications for virtually every condition caused or worsened by dominant defective genes, such as: Huntington's disease, familial high cholesterol, polycystic kidney disease, some instances of glaucoma and colorectal cancer, and neurofibromatosis, among others.
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- Scientists solve structure of gene regulator that plays key role in cancer
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Scientists at the Wistar Institute have collaborated on a major advance in understanding a gene regulator that contributes to some of the deadliest cancers in humans. Their research paves the way for the development of new cancer therapies. The scientists have elucidated the 3-D structure of a key segment of p300/CBP, one of the most studied enzymes in the HAT family. Aberrant p300/CBP activity contributes to pancreatic, colon, and lung cancer and also can suppress tumors.
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- Computer tool helps pinpoint risky gene mutations
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Certain cancer risks can be passed down through families, the result of tiny changes in a family's genetic code. But not all genetic changes are deadly. To help medical counselors and physicians identify the mutations that pose the greatest health risks, researchers have developed and validated a new computer tool.
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- Other highlights from the March 21 JNCI
03-20-2007 · EurekAlert!
Also in the March 21 JNCI are a study on the link between fat intake and breast cancer risk, a plant compound that may decrease breast cancer risk, a critique of the use of progression-free survival in cancer clinical trials, and a mutation to a mismatch repair gene that is associated with colorectal cancer.
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- Jefferson scientists see breast cancer gene activity from outside the body
11-28-2007 · EurekAlert!
Researchers at Jefferson Medical College and Jefferson's Kimmel Cancer Center in Philadelphia have used PET imaging to see hyperactive cancer genes inside breast tumors in laboratory animals, marking the first time such gene activity has been observed from outside the body. This technology might someday help physicians to detect and classify cancer, enabling them to find cancerous breast tumors as early as possible, and determine the appropriate treatment.
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- Scientists identify gene that may indicate predisposition to schizophrenia
01-24-2007 · EurekAlert!
In a study from the January issue of the American Journal of Human Genetics, a research team lead by Xinzhi Zhao and Ruqi Tang (Shanghai Jiao Tong University) present evidence that genetic variation may indicate predisposition to schizophrenia. Specifically, their findings identify the chitinase 3-like 1 gene as a potential schizophrenia-susceptibility gene and suggest that the genes involved in biological response to adverse conditions are likely linked to schizophrenia.
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- Low folate diets found to increase risk of colorectal cancer
11-02-2006 · EurekAlert!
A new study by scientists at the MUHC has revealed that a diet low in folate may increase the risk of developing colorectal cancer. Published in the scientific journal Cancer Research today, the study not only illustrates a way to prevent the disease but also provides further insight into the mechanisms of the disease, which could lead to novel therapies.
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