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Leukemic cells find safe haven in bone marrow
03-22-2007 · EurekAlert!The cancer drug asparaginase fails to help cure some children with acute lymphoblastic leukemia (ALL) because molecules released by certain cells in the bone marrow counteract the effect of that drug, according to investigators at St. Jude Children's Research Hospital.
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Keywords: leukemic, cells, safe, haven, bone, marrow, cell
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- Type of stem cell found to reside in transplanted lungs
03-08-2007 · EurekAlert!
A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated organs and with various kinds of lung disease.
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- Can you hear me now? Stem cells enhance hearing recovery
06-25-2007 · EurekAlert!
Researchers have shown that bone marrow stem cells injected into a damaged inner ear can speed hearing recovery after partial hearing loss. The related report by Kamiya et al, "Mesenchymal stem cell transplantation accelerates hearing recovery through the repair of injured cochlear fibrocytes," appears in the July issue of The American Journal of Pathology.
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- Adult stem cell application effective in treatment of peripheric vascular disease
01-24-2008 · EurekAlert!
Multipotent adult progenitor stem cells extracted from bone marrow, and known as MAPCs, have proved to be effective in the regeneration of blood vessel tissue and also in muscle tissue when treating peripheric vascular disease.
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- JCI table of contents -- March 22, 2007
03-22-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, March 22, 2007, in the JCI, including: New protein implicated in autism; Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns; Leukemic cells find protection from anticancer drug in the bone marrow; Inflammatory pathway leads to Duchenne muscular dystrophy; Protein’s role in blood clotting differs in vitro and in vivo; and Disease-causing genetic mutation reveals its molecular secrets.
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- Bone marrow microenvironment can contribute to blood cell disorder
06-14-2007 · EurekAlert!
Disorders of blood cells may begin in the biological environment where the cells develop, not just with the cells themselves, according to a study from researchers at the Massachusetts General Hospital and the Peter MacCallum Cancer Center in Melbourne, Australia.
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- Stroke victims may benefit from stem cell transplants
01-28-2008 · EurekAlert!
Two studies published in the current issue of Cell Transplantation examine the potential for cell transplants to benefit stroke victims. When injected into animal models and tracked via chemical tags and imaging, mensenchymal stem cells in one study, and bone marrow stromal cells in a second study, migrated within one to two weeks to affected brain areas and became therapeutically active. Both studies suggest that novel stem cell therapies can be developed.
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- First human trial tests stem-cell-based treatment for heart attacks
03-25-2007 · EurekAlert!
Previous research on the efficacy of stem cell therapy for heart repair has shown possible benefit from mesenchymal stem cells (MSCs) -- cells found in bone marrow that create connective tissue, bone and cartilage. A study presented today at the American College of Cardiology's Innovation in Intervention: i2 Summit reveals the results of the first human trial using MSCs for the treatment of myocardial infarction (MI, or heart attack).
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- U of MN adult stem cell research shows promise for transplant therapies
01-15-2007 · EurekAlert!
University of Minnesota stem cell researchers, together with collaborators at Stanford University, have successfully used adult stem cells to replace the immune system and bone marrow of mice, offering the promise of new therapies for people in the future.
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- Cancer cells enlist adult stem cells to promote metastasis
10-31-2007 · Massachusetts Institute of Technology (MIT)
MIT and Whitehead institute scientists have managed to facilitate metastasis, finding evidence that some breast cancer cells recruit normal adult stem cells from bone marrow and force them to secrete a protein that fosters cancer cell movement and invasion.
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- A faster way to recover from chemotherapy and marrow transplant
06-20-2007 · EurekAlert!
Researchers at Children's Hospital Boston report finding a practical way to increase stem cells in blood, suggesting a possible treatment to help patients recover from chemotherapy or bone marrow transplant for cancer, regaining immune function more quickly. The discovery, reported in the June 21 Nature and made possible through high-volume drug screening in fish, marks the first time stem-cell production has been induced by a small-molecule drug.
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