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Simulated populations used to probe gene mapping
03-23-2007 · EurekAlert!Statisticians and genetic epidemiologists from Rice University and The University of Texas M. D. Anderson Cancer Center have used computer simulations to trace genetic changes over thousands of generations in a simulated population to find out whether the tools that statistical geneticists use to pinpoint disease genes are up to the task of identifying multiple genes that cause complex diseases like cancer. The study is published this week in PLoS Genetics.
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Keywords: simulated, populations, used, probe, gene, mapping, population
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- A genetic variant increases the risk of developing schizophrenia in women
02-14-2008 · EurekAlert!
A complete scan of the human genome has revealed that a genetic variant in the Reelin gene increases the risk of developing schizophrenia in women only. Researchers from the Hebrew University of Jerusalem and the University of Oxford, who conducted the study in the Ashkenazi Jewish population, confirmed their findings by establishing a multinational collaboration that included populations and researchers from the United Kingdom, Ireland, United States, and China. Their research is published in the February issue of the open-access journal PLoS Genetics.
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- Genetic diversity of European Americans and disease gene mapping
01-17-2008 · EurekAlert!
In a recent study, published in the open-access journal PLoS Genetics, an international team of researchers provide the first genetic dissection of the population structure of European Americans, focusing on identifying the contributions from different genetic ancestries that are important for disease gene mapping.
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- Researchers witness natural selection at work in dramatic comeback of male butterflies
07-12-2007 · EurekAlert!
When an invasive bacteria ravaged the male embryos of the Blue Moon butterfly, it left populations that were nearly entirely female. But the males made an extraordinary comeback, going from 1 percent to 39 percent of the population in less than a year. Researchers at UC Berkeley and elsewhere witnessed this resurgence, and credited it to the rise of a suppressor gene that stopped the male-killing bacteria in its tracks.
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- A molecular map for aging in mice
11-28-2007 · EurekAlert!
Researchers at the National Institute of Aging and Stanford University have used gene arrays to identify genes whose activity changes with age in 16 different mouse tissues. The study, published Nov. 30 in PLoS Genetics, uses a newly available database called AGEMAP to document the process of aging in mice at the molecular level. The work describes how aging affects different tissues in mice, and ultimately could help explain why lifespan is limited to just two years in mice.
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- UCLA scientists identify new genetic link to autism
01-10-2008 · EurekAlert!
UCLA scientists used language onset -- the age when a child speaks his first word -- as a tool for identifying a new gene linked to autism. The team also discovered that the gene is most active in developing brain regions involved with language and thought. Interestingly, evidence for the genetic link came from the DNA of families with autistic boys, not those with autistic girls.
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- It takes a village -- Female ducks negotiate joint rearing of ducklings
01-10-2007 · EurekAlert!
Female eider ducks are well known to team up and share the work of rearing ducklings, but it now appears that they also negotiate not only how much effort each puts into the partnership, but also profit-sharing. An international group of scientists used a long-running study of the eider population in a Finnish archipelago to test predictions about how each hen seeks to maximize her benefits from the partnership without making it so unattractive that other hens withdraw their participation.
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- Whitefly secrets to success: how to become one of the world's top invasive species
11-08-2007 · EurekAlert!
A population of the whitefly Bemisia tabaci has become one of the world's worst invasive species -- devastating many crops in China and elsewhere in the process -- through mating behaviors that help it invade the territory of native whitefly populations, according to a new study conducted in China and Australia.
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- Study raises questions about diagnosis, medical treatment of ADHD
01-22-2008 · EurekAlert!
A new UCLA study shows that only about half of children diagnosed with attention-deficit hyperactivity disorder, or ADHD, exhibit the cognitive defects commonly associated with the condition and further, found that in populations where medication is rarely prescribed to treat ADHD, the prevalence and symptoms of the disorder are roughly equivalent to populations in which medication is widely used.
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- Gene variant shapes beta-blocker's effectiveness
01-20-2007 · Science News Online
A medication widely used for heart failure may be most effective in people who have a common variant of a particular gene.
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- Gene patenting -- steep cost for health care and patients
05-07-2007 · EurekAlert!
The drug trastuzumab (Herceptin) is used to treat HER2-positive breast cancer (a type of breast cancer that overexpresses the HER2 gene and accounts for about 25 percent of all breast cancers). Trastuzumab therapy improves the chances of survival; however, it has deleterious side effects and is expensive. Thus, it is important to accurately determine the patient's HER2 status.
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