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UT Southwestern leaders to receive national award for medical research accomplishments

03-20-2007 · UT Southwestern Medical Center

Two Nobel laureates from UT Southwestern Medical Center and their mentor, a distinguished chair of internal medicine at this institution, will receive Research!America's inaugural Builders of Science Award for their achievements in developing UT Southwestern into one of the world's premier research institutions.

Keywords: southwestern, leaders, receive, national, award, medical, research, accomplishments, leader, accomplishment

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UT Southwestern earns $34 million NIH grant to foster patient-oriented research
09-18-2007 · UT Southwestern Medical Center
UT Southwestern Medical Center will receive $34 million from the National Institutes of Health to lead a wide-ranging collaborative initiative aimed at speeding the transfer of laboratory discoveries to new therapies that improve human health.
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Ravenell named recipient of grant from Robert Wood Johnson Foundation
01-07-2008 · UT Southwestern Medical Center
Dr. Joseph Ravenell, assistant professor of internal medicine at UT Southwestern Medical Center, has received a Harold Amos Medical Faculty Development Award from the Robert Wood Johnson Foundation. The $416,558 award supports his research for the next four years.
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Advance in understanding of blood pressure gene could lead to new treatments
02-04-2007 · EurekAlert!
Research by scientists at UCL (University College London) has clearly demonstrated for the first time the structure and function of a gene crucial to the regulation of blood pressure. The discovery could be important in the search for new treatments for illnesses such as heart disease, the UK's biggest killer. In a paper published online today in Nature Medicine, the team, led by Professor Patrick Vallance and Dr James Leiper, UCL Department of Medicine, reveal the role of the human gene dimethylarginine dimethylaminohydrolase (DDAH), showing that loss of DDAH activity disrupts nitric oxide (NO) production. NO is critical in the regulation of blood pressure, nervous system functions and the immune system. The role of DDAH is to break down modified amino acids (Asymmetric dimethylarginine (ADMA) and monomethyl arginine (L-NMMA)) that are produced by the body and have been shown to inhibit NO synthase. These molecules accumulate in various disease states including diabetes, renal failure and pulmonary and systemic hypertension, and their concentration in plasma (the fluid component of blood) is strongly predicative of cardiovascular disease and death. In a healthy human body, the majority of ADMA is eliminated through active metabolism by DDAH. Scientists have hypothesised that if DDAH function is impaired, NO production is reduced, and that this could be an important feature of increased cardiovascular risk. To examine this pathway in more detail, the researchers deleted the DDAH gene in mice. These mice went on to develop hypertension, or high blood pressure. They also designed specific inhibitors (small molecules) which bind to the active site of human DDAH. These small molecule inhibitors also induced hypertension in mice, confirming the importance of DDAH in the regulation of blood pressure. Dr Leiper, UCL Medicine, said: “These genetic and chemical approaches to disrupt DDAH showed remarkably consistent results, and provide compelling evidence that loss of DDAH function increases the concentration of ADMA and thereby disrupts vascular NO signalling. “There has been considerable scientific interest in this pathway and the role of ADMA as a novel risk factor, but so far there's been little evidence to support the idea that it's a cause of disease, rather than just a marker. Genes and their pathways are crucial to our understanding of cardiovascular disease and a better understanding of DDAH-1 could lead to important new treatments. “It could help us to establish if genetic variation predisposes certain people to these diseases, or whether environmental factors exert some of their effects through modulation of DDAH activity. “Our research also shows that this pathway could be harnessed therapeutically to limit production of NO in certain situations where too much nitric oxide is a bad thing; for example, hypotension and septic shock. These are some of the biggest problems in intensive care medicine and there is a huge unmet need for drug treatments.” The study, which was carried out at UCL's Rayne Institute, was funded by grants from the British Heart Foundation, the Wellcome Trust and the Medical Research Council. Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, said: "The unexpected finding in the 1980s that a simple gas, nitric oxide (NO), is made by cells in the blood vessel wall and is a powerful control of blood vessel relaxation led to the award of the Nobel Prize in 1998 to its discoverers. "More recently, there has been increasing evidence that impairment of NO production is likely to be an important factor in the development of heart and circulatory disease, but the mechanisms responsible are not fully understood. "This study suggests for the first time that the loss of the activity of the enzyme DDAH-1 leads to reduced NO production and may cause heart and circulatory disease. These findings are likely to be important in the search for new ways to optimise the health of our blood vessels." ### Notes for Editors 1. For more information, please contact Ruth Metcalfe in the UCL Media Relations Office on tel: +44 (0)20 7679 9739, mobile: +44 (0)7990 675 947, out of hours: +44 (0)7917 271 364, e-mail: r.metcalfe@ucl.ac.uk2. 'Disruption of methylarginine metabolism impairs vascular homeostasis' is published in the February issue of the journal Nature Medicine. Advance online publication is embargoed to 18.00 GMT (13.00 US Eastern) Sunday 4 February 2007. Journalists can obtain copies of the paper by contacting the UCL Media Relations Office.3. The study was funded by the British Heart Foundation, the Wellcome Trust and the Medical Research Council. About UCL Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. In the government's most recent Research Assessment Exercise, 59 UCL departments achieved top ratings of 5* and 5, indicating research quality of international excellence. UCL is the fourth-ranked UK university in the 2006 league table of the top 500 world universities produced by the Shanghai Jiao Tong University. UCL alumni include Mahatma Gandhi (Laws 1889, Indian political and spiritual leader); Jonathan Dimbleby (Philosophy 1969, writer and television presenter); Junichiro Koizumi (Economics 1969, Prime Minister of Japan); Lord Woolf (Laws 1954, Lord Chief Justice of England & Wales); Alexander Graham Bell (Phonetics 1860s, inventor of the telephone), and members of the band Coldplay.
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UT Southwestern's obesity research receives $22 million NIH Roadmap grant
09-06-2007 · UT Southwestern Medical Center
UT Southwestern Medical Center's obesity research team has received a $22 million grant from the National Institutes of Health to enhance its groundbreaking efforts to attack obesity from every angle, from studying fat cells to developing medicines.
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UT Southwestern secures $5 million NIH grant for lupus research
12-19-2007 · UT Southwestern Medical Center
The division of rheumatic diseases in the Department of Internal Medicine at UT Southwestern Medical Center has been awarded a five-year, $5 million grant from the National Institutes of Health to fund the Center of Research Translation, which will investigate the autoimmune disease systemic lupus erythematosus (SLE).
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UT Southwestern scientist receives NIH Director's New Innovator Award
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Research needed to overcome bariatric surgery objections
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Anderson garners ORNL top honor at annual awards night
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Broad wins $200M for genomics research
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Summons wins Humboldt Award
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Roger E. Summons, a professor in the Department of Earth, Atmospheric and Planetary Sciences, will receive a Humboldt Research Award from the Alexander von Humboldt-Stifung Foundation in Germany.
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