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Targeting tumors the natural way
03-25-2007 · EurekAlert!By mimicking Nature's way of distinguishing one type of cell from another, University of Wisconsin-Madison scientists now report they can more effectively seek out and kill cancer cells while sparing healthy ones.
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Keywords: targeting, tumors, natural, way, tumor
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- Innovative movies show real-time immune-cell activity within tumors
11-20-2006 · EurekAlert!
Using advanced new microscopy techniques in concert with sophisticated transgenic technologies, scientists have for the first time created three-dimensional, time-lapse movies showing immune cells targeting cancer cells in live tumor tissues. Immune cells called T cells can be seen actively migrating though tissues, making direct contact with tumor cells, and killing them. Insights from this new view of the body's on-board defenses against cancer may open the way for improved immunotherapies to treat the disease.
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- Tumor-targeting viral therapy slows neuroblastoma, malignant peripheral nerve sheath tumors
02-15-2008 · EurekAlert!
Researchers in a multi-institutional study led by Cincinnati Children's Hospital Medical Center slowed the growth of two particularly stubborn solid tumor cancers -- neuroblastoma and peripheral nerve sheath tumors -- without harming healthy tissues by inserting instructions to inhibit tissue growth into an engineered virus, according to study results published in the Feb. 15 Cancer Research.
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- MicroRNA regulates cancer stem cells
12-13-2007 · EurekAlert!
Researchers have discovered a key molecular switch that regulates cancer stem cells. This switch, which belongs to a class of molecules called microRNAs, can decrease a cancer stem cell's ability to propagate tumors. These findings offer a way for targeting cancer stem cells directly, and as a result open up new avenues for potentially treating cancer as a whole.
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- Fat kills cancer
07-03-2007 · EurekAlert!
Researchers in Slovakia have been able to derive mesenchymal stem cells from human adipose, or fat, tissue and engineer them into "suicide genes" that seek out and destroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack small tumor metastases that evade current detection techniques and treatments, the researchers conclude in the July 1 issue of Cancer Research, a journal of the American Association for Cancer Research.
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- 'Super' enzyme may lead way to better tumor vaccines
12-03-2006 · EurekAlert!
A "super" form of the enzyme Akt1 could provide the key to boosting the effect of tumor vaccines by extending the lives of dendritic cells, the immune-system master switches that promote the response of T-cells, which attack tumors.
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- Natural mechanism for immune suppression paves way for cancer trials
03-28-2007 · EurekAlert!
A natural mechanism pirated by tumors and HIV to evade the immune response is opening the door to better treatment for these conditions, researchers say.
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- Therapeutic peptide frees the protein p73 to kill tumor cells
03-08-2007 · EurekAlert!
p53 suppresses tumor development by inducing tumor cell death. However, targeting p53 for the treatment of cancer is confounded by the fact that genetic mutations cause loss or inactivation of p53 in approximately 50 percent of human cancers. Now, a new study indicates that targeting the p53-related protein p73 in mice induces the regression of established tumors of human origin, leading to the suggestion that p73 might be a viable target for developing anticancer therapeutics.
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- Mayo discovers protein as potential tactic to prevent tumors
10-12-2006 · EurekAlert!
Mayo Clinic researchers have found that a protein that initiates a "quality control check" during cell division also directs cell death for those cells damaged during duplication. This knowledge represents a potential "bulls eye" for targeting anti-tumor drugs. The findings appear in the current issue of Science.
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- Study suggests test for p53 is needed to prescreen patients for blood cancer drugs
03-09-2007 · EurekAlert!
Researchers have determined a way to prescreen cancer patients to see if they are suitable candidates for proteasome inhibitors, a promising class of anti-cancer drugs. They propose to test for p53, a well-known tumor-suppressor protein that is broken down by cellular machinery called proteasomes.
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- Researchers at IRB Barcelona discover one of the mechanisms that prevents the spread of colon cancer
09-30-2007 · EurekAlert!
The first step in the development of colon cancer is the formation of benign tumors, called adenomas, in the intestine. Over time, these tumors may progress to produce colon cancer if they undergo a series of mutations and genetic alterations. Researchers at IRB Barcelona under the direction of Eduard Batlle, head of IRB Barcelona's Oncology Program, have discovered a new mechanism by which the benign tumor cells receive instructions to grow in confined compartments, and no to invade other areas of the tissue.
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