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Immune response to cancer stem cells may dictate cancer's course
03-26-2007 · EurekAlert!Mounting evidence shows that a tumor's growth and spread may depend on "cancer stem cells," which comprise only a very small subset of the tumor. A new study by Rockefeller University scientists shows that immunity to cancer stem cells may help protect people with a precancerous condition from developing the full-blown disease, and that these cells could be an important target for cancer vaccines.
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Keywords: immune, response, cancer, stem, cells, dictate, course, cell
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- Novel vaccine concept developed by scientists at the Wistar Institute
01-31-2008 · EurekAlert!
A new vaccine design strategy developed by scientists at the Wistar Institute could help to develop vaccines against diseases like AIDS and cervical cancer. The secret is using a herpes simplex protein called glycoprotein D to block a receptor molecule on antigen-presenting cells. Wistar scientists showed that vaccine vectors made by fusing glycoprotein D with genes from HIV and HPV antigens increase the immune system's response to those antigens in cell cultures and mice.
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- A faster way to recover from chemotherapy and marrow transplant
06-20-2007 · EurekAlert!
Researchers at Children's Hospital Boston report finding a practical way to increase stem cells in blood, suggesting a possible treatment to help patients recover from chemotherapy or bone marrow transplant for cancer, regaining immune function more quickly. The discovery, reported in the June 21 Nature and made possible through high-volume drug screening in fish, marks the first time stem-cell production has been induced by a small-molecule drug.
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- Brown researchers make major signal transduction discovery
10-04-2007 · EurekAlert!
How cells sense and respond to chemical messages -- a process known as signal transduction -- is a fundamental force in biology, controlling key processes such as cell growth and immune response. Now researchers from the Warren Alpert Medical School of Brown University and Rhode Island Hospital report a significant discovery in the field of signal transduction that could provide a new target for drugs that fight cancer, HIV and diseases. Results are published in Cell.
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- New insight into factors that drive muscle-building stem cells
01-08-2008 · EurekAlert!
A report in the January issue of Cell Metabolism, a publication of Cell Press, provides new evidence explaining how stem cells known as satellite cells contribute to building muscles up in response to exercise. These findings could lead to treatments for reversing or improving the muscle loss that occurs in diseases such as cancer and AIDS as well as in the normal aging process
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- Tumor-reactive T cells boosted by hematopoietic stem cell transplantation
02-01-2007 · EurekAlert!
Treatment for skin cancer by infusion of tumor-reactive T cells requires patients to be pre-treated with agents that transiently decrease the number of immune cells (nonmyeloablative agents). A study in mice now indicates that pre-treatment with more intense immune cell-depleting strategies (known as myeloablative strategies) and a hematopoietic stem cell transplant enables infused tumor-reactive CD8+ T cells to increase in number more than pre-treatment with nonmyeloablative agents, and this correlates with increased tumor regression.
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- Loss of stem cells correlates with premature aging in animal study
06-06-2007 · EurekAlert!
Researchers at the Abramson Family Cancer Research Institute of the University of Pennsylvania have found that deleting a gene important in embryo development leads to premature aging and loss of stem cell reservoirs in adult mice. This gene, ATR, is essential for the body's response to damaged DNA, and mutations in proteins in the DNA damage response underlie certain types of cancer and other disorders in humans.
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- Stem cell transplant can grow new immune system in certain mice, Stanford researchers find
11-22-2007 · EurekAlert!
Researchers at the Stanford University School of Medicine have taken a small but significant step, in mouse studies, toward the goal of transplanting adult stem cells to create a new immune system for people with autoimmune or genetic blood diseases.
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- MIT model could predict cells' response to drugs
07-30-2007 · EurekAlert!
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- Team finds way to create cancer stem cells
08-13-2007 · Massachusetts Institute of Technology (MIT)
MIT scientists and colleagues have found a way to create in the lab large amounts of cancer stem cells, or cells that can initiate tumors. The work, reported in the August 13 issue of Cancer Cell, could be a boon to researchers who study these elusive cells.
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- Patient with rare disorder responds to cancer drug
02-13-2008 · EurekAlert!
A rare disorder caused by an excess of two types of immune cells -- the mast cell found in various tissues and its blood-based twin, the basophil -- has successfully been treated with a cancer drug, report scientists from NIAID.
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