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Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation

Rheumatoid arthritis (RA) is caused by the immune system inappropriately attacking the joints. The autoimmune response also leads to the recruitment and/or differentiation of cells known as osteoclasts -- cells that degrade and resorb bone. Current treatments for RA target either the joint-specific immune response or the osteoclast-mediated bone erosion but a new study suggests that targeting a protein known as PLC-gamma-2 might lead to control of both immune-mediated joint destruction and osteoclast-mediated bone erosion.

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Keywords: double, trouble, patients, plc-gamma-2, regulates, osteoclastogenesis, cell, differentiation, patient, plc, gamma, regulate, osteoclastogenesi

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