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Fruit fly gene research may shed light on human disease processes
03-27-2007 · EurekAlert!Those small fruit flies buzzing around your bananas are more than pests -- they may be allies in a fruitful search for clues to human diseases caused when genes malfunction.
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Keywords: fruit, fly, gene, research, shed, light, human, disease, processes, processe
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- Non-steroidal anti-inflammatory drug increases liver damage in mice carrying mutant human gene
11-15-2006 · EurekAlert!
Research performed at Washington University School of Medicine in St. Louis sheds light on the mechanisms that contribute to liver disease in alpha-1-AT deficiency patients. People with alpha-1-deficiency have a genetic mutation that can lead to emphysema at an early age and to liver damage. Using an experimental mouse model of the disorder, the researchers investigated the effects of a non-steroidal anti-inflammatory drug on liver injury.
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- Environmental epigenetics has potential for preventing and treating disease
01-31-2008 · EurekAlert!
New research on environmental influences on health and disease has begun to shed light on why genetically identical individuals demonstrate different characteristics, such as susceptibility to disease. Scientists have found that environmental exposure to nutritional, chemical and physical factors can alter the epigenome. Literally meaning "above the genome," the epigenome refers to differences in gene expression that are inherited without changing the sequence of DNA.
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- Blind mice shed light on human sight loss
11-21-2007 · EurekAlert!
Mutant mice could provide genetic clues to understanding incurable human sight loss resulting from retinal degeneration. Research published in the online open access journal Genome Biology uncovers a role for microRNA in retinal disease, and may point the way to future therapies.
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- 'Drunk' fruit flies could shed light on genetic basis of human alcohol abuse
10-19-2006 · EurekAlert!
Fruit flies get "drunk," just like humans, when exposed to large amounts of alcohol and may in future help to explain why some people are genetically predisposed to alcohol abuse. Humans and fruit flies respond to alcohol in a very similar way at the gene level, according to a study published today in the open access journal Genome Biology.
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- Research links genetic mutations to lupus
07-29-2007 · EurekAlert!
A gene discovered by scientists at Wake Forest University School of Medicine has been linked to lupus and related autoimmune diseases. The finding, reported in the current issue of Nature Genetics, is the latest in a series of revelations that shed new light on what goes wrong in human cells to cause the diseases.
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- New research shows how H5N1 virus causes disease
09-27-2007 · EurekAlert!
Researchers at Beijing University, Columbia University Mailman School of Public Health, and SUNY Downstate report in the Lancet detailed studies of human H5N1 victims that shed light on the anatomic distribution of the virus and its pathogenesis. Using a combination of molecular and protein labeling techniques, the authors found that H5N1 is present in the gastrointestinal tract and immune and central nervous systems, as well as the respiratory tract.
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- Reprogrammed human adult stem cells rescue diseased muscle in mice
12-12-2007 · EurekAlert!
Scientists report that adult stem cells isolated from humans with muscular dystrophy can be genetically corrected and used to induce functional improvement when transplanted into a mouse model of the disease. The research, published by Cell Press in the December issue of Cell Stem Cell, represents a significant advance toward the future development of a gene therapy that uses a patient's own cells to treat this devastating muscle-wasting disease.
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- p53 gene mutations and inflammation trigger skin cancer
07-02-2007 · EurekAlert!
Squamous cell carcinoma (SCC) is a form of nonmelanoma skin cancer, which is the most common type of human malignancy with over 1 million new cases in the USA each year. In the July 2 issue of the Journal of Clinical Investigation, two separate studies by research teams at Glasgow University and Baylor College of Medicine uncover 2 previously unidentified regulators of SCC development, providing insights into the development of this potentially lethal disease.
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- Fighting like a girl or boy determined by gene in fruit flies
11-19-2006 · EurekAlert!
Fighting like a girl or fighting like a boy is hardwired into fruit fly neurons, according to a study in the November 19 Nature Neuroscience advance online publication by a research team from Harvard Medical School and the Institute of Molecular Pathology in Vienna. The results confirm that a gene known as "fruitless" is a key factor underlying sexual differences in behavior.
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- Scientists compare 12 fruit fly genomes
11-07-2007 · EurekAlert!
An international research consortium of scientists, supported by the National Human Genome Research Institute, part of the National Institutes of Health, today announced publications comparing the genome sequences of 12 closely related fruit fly species, 10 of which were sequenced for the first time. The analyses identify thousands of novel genes and other functional elements in the insects' genomes, and describe how evolution has shaped the genomes of these important models for genetic research.
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