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A newly identified immunosuppressive protein in rheumatoid arthritis
03-28-2007 · EurekAlert!The findings of a new study expose DcR3 as one of the factors culpable for RA's hallmark hyperplasia and its crippling consequences.
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Keywords: newly, identified, immunosuppressive, protein, rheumatoid, arthritis, arthriti
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- Penn researchers discover how key protein stops inflammation
08-07-2007 · EurekAlert!
Researchers recently identified how a regulatory protein called Bcl-3 helps to control the body's inflammation response to infection by interfering a critical biochemical process called ubiquitination. Their findings open new avenues for developing therapies to treat such diseases as sepsis, diabetes and rheumatoid arthritis.
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- Blood clotting protein linked to rheumatoid arthritis
11-16-2007 · EurekAlert!
Researchers at Cincinnati Children's have issued the first study showing that a protein involved in blood clotting (fibrin), also plays an important role in the development of rheumatoid arthritis. Inflammatory joint disease appears to be driven by the engagement of inflammatory cells with fibrin matrices through a specific integrin receptor, aMD2. Researchers suggest that therapies designed to interrupt the localized interaction of inflammatory cells and fibrin may help arthritis patients.
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- TNF-alpha antagonist stops inflammation-induced colon cancer in its tracks
01-24-2008 · EurekAlert!
Individuals with the inflammatory bowel disease ulcerative colitis are at increased risk of developing colon cancer. New data have identified a central role for the soluble factor TNF-alpha in the development of colon cancer in mice induced to have inflammatory bowel disease. These data provide clear rationale for the idea that drugs antagonizing TNF-alpha (such as those used to treat rheumatoid arthritis) might reduce the risk of colon cancer in individuals with UC.
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- JCI table of contents: December 1, 2006
12-01-2006 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for newsworthy papers to be published December 1, 2006, in the JCI, including: Silencing the cause of mad cow disease; Immune responses spread from one protein to another in type 1 diabetes; Fat tissue gains weight from the bone marrow; Immune cells get together in the lung of patients with rheumatoid arthritis; PDE3B regulates energy levels in mice; and others.
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- Researchers identify genes that increase rheumatoid arthritis risk
10-04-2007 · EurekAlert!
Researchers in the United States and Sweden have identified a genetic region associated with increased risk of rheumatoid arthritis, a chronic and debilitating inflammatory disease of the joints that affects an estimated 2.1 million Americans. The US arm of the study involved a long-time collaboration between intramural researchers of the National Institute of Arthritis and Musculoskeletal and Skin Diseases and other organizations. NIAMS is one of 27 institutes and centers at the National Institutes of Health.
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- Molecule linked to autoimmune disease relapses identified at Stanford
12-03-2006 · EurekAlert!
The ebb and flow of such autoimmune diseases as multiple sclerosis, lupus and rheumatoid arthritis has long been a perplexing mystery to scientists. But new findings from the Stanford University School of Medicine bring scientists closer to solving the puzzle, identifying a molecule that appears to play a central role in these relapses.
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- Double trouble for RA patients: PLC-gamma-2 regulates osteoclastogenesis and B cell differentiation
10-19-2006 · EurekAlert!
Rheumatoid arthritis (RA) is caused by the immune system inappropriately attacking the joints. The autoimmune response also leads to the recruitment and/or differentiation of cells known as osteoclasts -- cells that degrade and resorb bone. Current treatments for RA target either the joint-specific immune response or the osteoclast-mediated bone erosion but a new study suggests that targeting a protein known as PLC-gamma-2 might lead to control of both immune-mediated joint destruction and osteoclast-mediated bone erosion.
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- Discovery could lead to new autoimmune therapies
01-22-2007 · Massachusetts Institute of Technology (MIT)
Scientists from MIT, the Whitehead Institute and the Dana-Farber Cancer Institute have identified a key set of genes that may help scientists develop therapies for autoimmune diseases such as type 1 diabetes, lupus and rheumatoid arthritis.
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- Newly identified mechanism for silencing genes points to possible anti-cancer strategies
05-16-2007 · EurekAlert!
Scientists are only beginning to appreciate the extraordinary degree of control exercised over every step of the gene-to-protein production process. Only about 10 percent of human genes, for example, are active in a given cell at a given time, with the remaining 90 percent silenced by a various mechanisms. In a just-published study in Nature, scientists report an important new gene-silencing mechanism that points to promising potential targets for anti-cancer interventions.
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- Manchester researchers identify gene behind rheumatoid arthritis
11-04-2007 · EurekAlert!
University of Manchester researchers have identified a genetic variant in a region on chromosome 6 that is associated with rheumatoid arthritis, the most common inflammatory arthritis affecting 387,000 people in the UK.
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