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Brain tissue reveals possible genetic trigger for schizophrenia

03-28-2007 · EurekAlert!

A study led by scientists from the University of North Carolina at Chapel Hill may have identified a molecular mechanism involved in the development of schizophrenia.

Keywords: brain, tissue, reveals, possible, genetic, trigger, schizophrenia, reveal

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JCI table of contents -- February 8, 2006
02-08-2007 · EurekAlert!
This release contains summaries, links to PDFs and contact information for the following newsworthy papers to be published online, February 8, 2006, in the JCI, including: Vitamin D3 provides the skin with protection from harmful microbes; Possible genetic link to schizophrenia identified; Efficient consumption of copper allows fungus to infect the brain; Don’t stop here: why only some cystic fibrosis patients respond to treatments that prevent the generation of truncated proteins; and others.
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Possible genetic link to schizophrenia identified
02-08-2007 · EurekAlert!
Several neurological and psychiatric disorders, including schizophrenia, are associated with changes in the brain that affect nerves that communicate with each other using dopamine. One protein that is crucial for dopamine-mediated neuronal communication in animals is DARPP-32. Now, researchers have shown that the gene that encodes DARPP-32 in humans exhibits genetic variation and that one particular variant is associated with increased performance in a number of cognitive tests and with an increased risk of schizophrenia.
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Researchers discover possible markers for mental illness
12-03-2007 · EurekAlert!
Researchers have discovered natural genetic differences that might help predict the most effective antipsychotic drugs for particular patients with mental disorders such as schizophrenia, Parkinson's and drug addiction. They found the differences in the gene for a molecule called the dopamine D2 receptor, a protein present on brain cells that are sensitive to the neurotransmitter dopamine.
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Imaging study reveals rapid formation of Alzheimer's-associated plaques
02-06-2008 · EurekAlert!
The amyloid plaques found in the brains of Alzheimer's disease patients may form much more rapidly than previously expected. Using an advanced microscopic imaging technique to examine brain tissue in mouse models of the devastating neurological disorder, researchers from the MassGeneral Institute for Neurodegenerative Disease find that plaques can develop in as little as a day and that Alzheimer's-associated neuronal changes appear soon afterwards.
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Common gene version optimizes thinking -- but with a possible downside
02-08-2007 · EurekAlert!
Most people inherit a version of a gene that optimizes their brain's thinking circuitry, yet also appears to increase risk for schizophrenia, a severe mental illness marked by impaired thinking. The seeming paradox emerged from the first study to explore the effects of variation in the human gene for a brain master switch, DARPP-32. The gene impacts the way two key brain regions exchange information, affecting a range of functions from general intelligence to attention.
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Potential genetic testing for substance abuse raises hope, concern
03-06-2007 · EurekAlert!
Now it is possible to develop similar tests that reveal a person's potential to become dependent on nicotine or marijuana or have antisocial personality disorder, University of Iowa researchers report online March 6 in the American Journal of Medical Genetics.
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Study points to a genetic link for schizophrenia
02-20-2007 · Massachusetts Institute of Technology (MIT)
Gene mutations governing a key brain enzyme make people susceptible to schizophrenia and may be targeted in future treatments for the psychiatric illness, according to MIT and Japanese researchers.
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Studies elucidate genetic links between cancer and schizophrenia
12-08-2007 · EurekAlert!
A series of studies presented today at the American College of Neuropsychopharmacology Annual Meeting elucidates evidence that there is a genetic link between schizophrenia and cancer, providing a surprising possible scientific explanation for lower rates of cancer among patients with schizophrenia -- despite having poor diets and high rates of smoking -- and their parents.
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UCSF stem cell study reveals cells' capability in mouse brain tissue repair
12-14-2006 · EurekAlert!
UCSF scientists have determined that adult stem cells in a specific region of the mouse brain have a built-in mechanism that allows the cells to participate in the repair and remodeling of damaged tissue in the region.
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Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
12-03-2007 · EurekAlert!
Scientists at the Zucker Hillside Hospital campus of the Feinstein Institute for Medical Research have identified nine genetic markers that can increase a person's risk for schizophrenia. In a study published this week in the Proceedings of the National Academy of Sciences, the research team uncovered original evidence that this disabling brain disease can be inherited in a recessive manner. A recessive trait is one that is inherited from both parents.
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