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New therapeutic insight into duchenne muscular dystrophy
03-31-2007 · EurekAlert!In the April 1 issue of Genes & Development, Dr. Bruce Spiegelman (Dana Farber Cancer Institute) and colleagues identify a key genetic component of and possible therapeutic target for Duchenne muscular dystrophy.
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Keywords: therapeutic, insight, duchenne, muscular, dystrophy
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- Common blood pressure drug treats muscular dystrophy in mice
01-21-2007 · EurekAlert!
Researchers at Johns Hopkins have shown that a drug commonly used to lower blood pressure reverses muscle wasting in genetically engineered mice with Marfan syndrome and also prevents muscle degeneration in mice with Duchenne muscular dystrophy. The results are reported online this week at Nature Medicine.
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- Common blood pressure drug reduces progressive muscle degeneration in mice
02-02-2007 · EurekAlert!
Scientists supported in part by the National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and National Institute of Neurological Disorders and Stroke (NINDS) have found that that the commonly prescribed blood pressure medication losartan improves muscle regeneration and repair in a mouse model of Duchenne muscular dystrophy (DMD), a devastating disease characterized by rapid progression of muscle degeneration in boys and young men.
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- JCI table of contents -- March 22, 2007
03-22-2007 · EurekAlert!
This release contains summaries, links to PDFs, and contact information for the following newsworthy papers to be published online, March 22, 2007, in the JCI, including: New protein implicated in autism; Prenatal exposure to glucocorticoids has long-term deleterious effects on newborns; Leukemic cells find protection from anticancer drug in the bone marrow; Inflammatory pathway leads to Duchenne muscular dystrophy; Protein’s role in blood clotting differs in vitro and in vivo; and Disease-causing genetic mutation reveals its molecular secrets.
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- First demonstration of muscle restoration in an animal model of Duchenne muscular dystrophy
04-22-2007 · EurekAlert!
Using a new type of drug that targets a specific genetic defect, researchers at the University of Pennsylvania School of Medicine, along with colleagues at PTC Therapeutics Inc. and the University of Massachusetts Medical School, have for the first time demonstrated restoration of muscle function in a mouse model of Duchenne's muscular dystrophy (DMD).
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- Daily steroids help boys with muscular dystrophy walk longer
05-07-2007 · EurekAlert!
Boys with Duchenne muscular dystrophy were able to walk on their own for a longer period of time and reduce their risk of scoliosis as a result of receiving daily steroid treatments for several years, according to a study published in the May 8, 2007, issue of Neurology, the scientific journal of the American Academy of Neurology.
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- Penn researchers find a new target for muscular dystrophy drug therapy
07-12-2007 · EurekAlert!
Researchers report how the gene for utrophin, which codes for a protein very similar to dystrophin, the defective protein in Duchenne muscular dystrophy, puts the brakes on its own expression in muscle cells, thereby suggesting a new target for treatment.
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- New clinical trial results show how personalized medicine will alter treatment of genetic disorders
12-26-2007 · EurekAlert!
In the latest edition of the New England Journal of Medicine, Eric Hoffman, PhD, posits that the results of a clinical trial involving a new treatment for Duchenne muscular dystrophy provides a proof-of-principle for personalized molecular medicine. He writes that advances allowing for systemic delivery of such drugs and provide proof of no long term toxicity for recipients are necessary but will likely come in short order. Moving forward, FDA regulations will prove critical for appropriate labeling and marketing of such personalized treatments.
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- Stem-cell transplantation improves muscles in MD animal model, UT Southwestern researchers report
01-20-2008 · EurekAlert!
Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy -- and more importantly, functioning -- muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.
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- Stem-cell transplantation improves muscles in animal model of muscular dystrophy, researchers report
01-21-2008 · UT Southwestern Medical Center
Using embryonic stem cells from mice, UT Southwestern Medical Center researchers have prompted the growth of healthy — and more importantly, functioning — muscle cells in mice afflicted with a human model of Duchenne muscular dystrophy.
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- Mouse with myotonic dystrophy type 1 finds RNA binding proteins at heart of problem
09-05-2007 · EurekAlert!
A new mouse model for myotonic dystrophy - the most common form of adult-onset muscular dystrophy - helped Baylor College of Medicine researchers show that levels of CUGBP1, a protein that binds and controls the activity of the genetic material RNA, increase early in affected cells of the animals with the disease. This means CUGBP1 plays a key role in the disorder.
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