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Jefferson scientists find rabies-based vaccine could be effective against HIV
04-03-2007 · EurekAlert!Rabies, a relentless, ancient scourge, may hold a key to defeating another implacable foe: HIV. Scientists have used a drastically weakened rabies virus to ferry HIV-related proteins into animals, in essence, vaccinating them against an AIDS-like disease. Early evidence indicates that the vaccine -- which doesn’t protect against infection -- prevents development of disease. Two years after the initial vaccination, four non-human primates were protected from disease, even after being "challenged" with a dangerous animal-human virus.
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Keywords: jefferson, scientists, rabies-based, vaccine, effective, hiv, scientist, rabies, based
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A molecule thought crucial to ferrying the deadly rabies virus into the brain, where it eventually kills, apparently isn't. Instead, the protein complex LC8 is actually involved in virus reproduction. The surprising finding, say researchers at Jefferson Medical College in Philadelphia, may change the way scientists think about how central nervous system-attacking viruses such as herpes viruses invade the brain and cause disease.
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